Table 4.

Human astrocyte genes upregulated by TGRL lipolysis products

Gene IDGene TitleGene SymbolFold Change
Apoptosis and cell cycle
    NM_021732Arginine vasopressin-induced 1AVPI16.66
    U37546Baculoviral IAP repeat-containing 3BIRC32.64
    AW504018BMP2 inducible kinaseBMP2K2.27
    AA583044Bone morphogenetic protein 2BMP22.62
    AI251890CDC-like kinase 1CLK12.95
    AF212224CDC-like kinase 4CLK42.06
    NM_004748Cell cycle progression 1CCPG12.22
    AW134535Cyclin G2CCNG22.53
    AV681875Cyclin T2CCNT22.32
    BC003637DNA-damage-inducible transcript 3DDIT36.88
    AW613387Endothelial cell growth factor 1 (platelet-derived)ECGF12.12
    BC005161Inhibin, β EINHBE4.66
    AA747426Interferon-related developmental regulator 1IFRD12.60
    NM_002392Mdm2MDM22.63
    NM_001932Membrane protein, palmitoylated 3MPP32.13
    NM_022337RAB38, member RAS oncogene familyRAB382.34
    NM_030751SNF1-like kinaseSNF1LK5.08
    NM_003378VGF nerve growth factor inducibleVGF2.07
    NM_000222v-kit Hardy-Zuckerman 4 feline sarcoma viral Oncogene homologKIT4.64
Inflammatory response
    AL564683CCAAT/enhancer binding protein (C/EBP), βCEBPB2.59
    M83667CCAAT/enhancer binding protein (C/EBP), δCEBPD3.09
    AA700015CD58 moleculeCD582.13
    NM_004591Chemokine (C-C motif) ligand 20CCL209.42
    NM_001511Chemokine (C-X-C motif) ligand 1CXCL112.48
    M57731Chemokine (C-X-C motif) ligand 2CXCL275.26
    NM_002090Chemokine (C-X-C motif) ligand 3CXCL350.61
    NM_002993Chemokine (C-X-C motif) ligand 6CXCL62.48
    AI817041Chemokine (C-X-C motif) receptor 7CXCR74.73
    NM_005261GTP binding protein overexpressed in skeletal muscleGEM2.67
    M15329Interleukin 1, αIL1A3.72
    M15330Interleukin 1, βIL1B2.26
    M57765Interleukin 11IL112.13
    Y09908Interleukin 15IL152.86
    NM_000600Interleukin 6 (interferon, β 2)IL63.20
    NM_000584Interleukin 8IL82.44
    AF010316Prostaglandin E synthasePTGES2.21
    NM_000963Prostaglandin-endoperoxide synthase 2PTGS25.87
    U59863TRAF family member-associated NF-KB activatorTANK2.14
    BF433902Tumor necrosis factor receptor superfamily, member 11bTNFRSF11B2.29
    NM_006290Tumor necrosis factor, α-induced protein 3TNFAIP33.31
    AF022375Vascular endothelial growth factor AVEGFA2.36
Metabolism
    NM_022977Acyl-CoA synthetase long-chain family member 4ACSL42.21
    NM_001673Asparagine synthetaseASNS2.26
    AK000993Asparagine synthetase pseudogeneASNS2.06
    AF073310Insulin receptor substrate 2IRS22.33
    NM_005907Mannosidase, alpha, class 1A, member 1MAN1A12.15
    AA621558Methionyl-tRNA synthetaseMARS5.86
    NM_004563Phosphoenolpyruvate carboxykinase 2PCK23.24
    NM_006931Solute carrier family 2 (facilitated glucose transporter), member 3SLC2A32.13
    AI989567ST3 β-galactoside alpha-2,3-sialyltransferase 6ST3GAL62.39
    X15132Superoxide dismutase 2, mitochondrialSOD22.31
    L22431Very low density lipoprotein receptorVLDLR2.17
Transcription factors
    NM_001674Activating transcription factor 3ATF36.41
    NM_019058DNA-damage-inducible transcript 4DDIT48.06
    NM_004836Eukaryotic translation initiation factor 2-α kinase 3EIF2AK32.57
    BC000529Growth differentiation factor 15GDF152.37
    BC005329Heat shock transcription factor 2HSF22.41
    AA149594Kruppel-like factor 11KLF113.04
    NM_016270Kruppel-like factor 2 (lung)KLF22.20
    AF285837Kruppel-like factor 3 (basic)KLF32.14
    BF514079Kruppel-like factor 4 (gut)KLF49.59
    AF132818Kruppel-like factor 5 (intestinal)KLF54.90
    NM_001206Kruppel-like factor 9KLF92.29
    NM_005920Myocyte enhancer factor 2DMEF2D2.37
    NM_002502Nuclear factor of kappa light polypeptide gene Enhancer in B cells 2NFKB22.12
    NM_020529Nuclear factor of κ light polypeptide gene Enhancer in B cells inhibitor, αNFKBIA2.38
    NM_005384Nuclear factor, interleukin 3 regulatedNFIL33.24
    S77154Nuclear receptor subfamily 4, group A, member 2NR4A225.94
    AL110191TSC22 domain family, member 3TSC22D32.64
    BC004490v-fos FBJ murine osteosarcoma viral oncogene homologFOS4.42
    NM_014950Zinc finger and BTB domain containing 1ZBTB12.03
    AK025663Zinc finger protein 291ZNF2912.00
    BF223237Zinc finger protein 292ZNF2922.06
    NM_018555Zinc finger protein 331ZNF3314.39
    AK021474Zinc finger protein 440ZNF4402.06
    AU144775Zinc finger protein 451ZNF4513.35
    NM_016536Zinc finger protein 571ZNF5712.03
    NM_014789Zinc finger protein 623ZNF6232.18
    NM_022103Zinc finger protein 667ZNF6672.22
    NM_021998Zinc finger protein 711ZNF7112.11
    R51161Zinc finger protein, X-linkedZFX2.22
  • Genes shown to be upregulated in astrocytes by lipolysis product treatment are classified functionally into apoptosis/cell cycle, inflammatory responses, metabolism, and transcription factors classes.