Table 3.

Significantly enriched GO terms of the highly expressed genes in human astrocytes treated with LpL, TGRL, or TGRL + LpL

GO IDGO TermLpLTGRLTGRL + LpL
GO:0042127Regulation of cell proliferation6.09E-11
GO:0010604Positive regulation of macromolecule metabolic process2.81E-08
GO:0031328Positive regulation of cellular biosynthetic process4.60E-08
GO:0009891Positive regulation of biosynthetic process6.66E-08
GO:0008284Positive regulation of cell proliferation8.68E-08
GO:0010557Positive regulation of macromolecule biosynthetic process1.38E-07
GO:0051173Positive regulation of nitrogen compound metabolic process8.67E-07
GO:0008285Negative regulation of cell proliferation1.24E-06
GO:0016265Death1.49E-06
GO:0045449Regulation of transcription1.65E-06
GO:0006357Regulation of transcription from RNA polymerase II promoter1.65E-06
GO:0008083Growth factor activity2.60E-06
GO:0043067Regulation of programmed cell death2.97E-06
GO:0010941Regulation of cell death3.22E-06
GO:0008219Cell death3.49E-06
GO:0003700Transcription factor activity3.57E-06
GO:0045935Positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process3.60E-06
GO:0005125Cytokine activity5.25E-06
GO:0042981Regulation of apoptosis6.08E-06
GO:0010628Positive regulation of gene expression6.97E-06
GO:0045941Positive regulation of transcription1.12E-05
GO:0051254Positive regulation of RNA metabolic process1.58E-05
GO:0006355Regulation of transcription, DNA-dependent1.75E-05
GO:0001666Response to hypoxia1.76E-05
GO:0051252Regulation of RNA metabolic process1.77E-05
GO:0030528Transcription regulator activity1.77E-05
GO:0012501Programmed cell death1.80E-05
GO:0005615Extracellular space2.52E-05
GO:0070482Response to oxygen levels2.93E-05
GO:0009617Response to bacterium3.90E-05
GO:0045893Positive regulation of transcription, DNA-dependent3.93E-05
GO:0001568Blood vessel development3.98E-05
GO:0043069Negative regulation of programmed cell death4.36E-05
GO:0003677DNA binding4.52E-05
GO:0060548Negative regulation of cell death4.56E-05
GO:0016477Cell migration4.81E-05
GO:0001944Vasculature development5.34E-05
GO:0002237Response to molecule of bacterial origin5.92E-05
GO:0046983Positive regulation of transcription from RNA polymerase II promoter6.82E-05
GO:0007610Behavior8.48E-05
GO:0005730Nucleolus9.12E-05
GO:0048514Blood vessel morphogenesis1.02E-04
GO:0043066Negative regulation of apoptosis1.11E-04
GO:0043232Intracellular nonmembrane-bounded organelle1.18E-04
GO:0043228Nonmembrane-bounded organelle1.18E-04
GO:0051781Positive regulation of cell division1.22E-04
GO:0044421Extracellular region part1.43E-04
GO:0051960Regulation of nervous system development1.48E-04
GO:0009991Response to extracellular stimulus1.59E-04
GO:0035295Tube development1.59E-04
GO:0031974Membrane-enclosed lumen1.66E-04
GO:0048870Cell motility1.76E-04
GO:0051674Localization of cell1.76E-04
GO:0022405Hair cycle process1.86E-04
GO:0001942Hair follicle development1.86E-04
GO:0022404Molting cycle process1.86E-04
GO:0009611Response to wounding1.96E-04
GO:0001525Angiogenesis2.12E-04
GO:0042633Hair cycle2.12E-04
GO:0042303Molting cycle2.12E-04
GO:0007049Cell cycle2.29E-04
GO:0043433Negative regulation of transcription factor activity2.74E-04
GO:0051302Regulation of cell division3.49E-04
GO:0031981Nuclear lumen3.59E-04
GO:0043233Organelle lumen3.63E-04
GO:0016564Transcription repressor activity3.93E-04
GO:0006350~Transcription3.96E-04
GO:0006935Chemotaxis4.16E-04
GO:0042330Taxis4.16E-04
GO:0045596Negative regulation of cell differentiation4.65E-04
GO:0051241Negative regulation of multicellular organismal process5.13E-04
GO:0042325Regulation of phosphorylation5.36E-04
GO:0006915Apoptosis5.41E-04
GO:0043392Negative regulation of DNA binding5.48E-04
GO:0007243Protein kinase cascade5.49E-04
GO:0050767Regulation of neurogenesis5.68E-04
GO:0009719Response to endogenous stimulus6.02E-04
GO:0031667Response to nutrient levels6.87E-04
GO:0070013Intracellular organelle lumen7.21E-04
GO:0010033Response to organic substance7.28E-04
GO:0006952Defense response7.34E-04
GO:0046983Protein dimerization activity7.54E-04
GO:0051101Regulation of DNA binding7.87E-04
GO:0007242Intracellular signaling cascade8.06E-04
GO:0006955Immune response8.08E-04
GO:0019220Regulation of phosphate metabolic process8.95E-04
GO:0051174Regulation of phosphorus metabolic process8.95E-04
GO:0032496Response to lipopolysaccharide9.30E-04
GO:0060284Regulation of cell development9.74E-04
GO:0006916Antiapoptosis0.00102
GO:0031327Negative regulation of cellular biosynthetic process0.00106
GO:0016481Negative regulation of transcription0.00109
GO:0035239Tube morphogenesis0.00111
GO:0051098Regulation of binding0.00111
GO:0051090Regulation of transcription factor activity0.00116
GO:0051726Regulation of cell cycle0.00119
GO:0051100Negative regulation of binding0.00120
GO:0022409Positive regulation of cell-cell adhesion0.00120
GO:0009890Negative regulation of biosynthetic process0.00142
GO:0008283Cell proliferation0.00145
GO:0032583Regulation of gene-specific transcription0.00162
GO:0006928Cell motion0.00165
  • DAVID was selected to perform functional enrichment analysis to determine enrichment for Gene Ontology (GO) biological process (GO terms). Statistical significance was determined using one-tailed Fishers’ extract test and Benjamini correction; adjusted P ≤ 0.05 between two groups was considered significant.