Table 5.

Human astrocyte genes downregulated by TGRL lipolysis products

Gene IDGene TitleGene SymbolFold Change
Apoptosis and cell cycle
    AW205153Caspase recruitment domain family, member 10CARD10−2.32
    BF686824Death-associated protein kinase 3DAPK3−2.04
    AA215854Integrin, β1ITGB1−5.62
    BC001422Placental growth factorPGF−2.99
    NM_004749Transforming growth factor β regulator 4TBRG4−2.01
Infammatory response
    NM_017544NF-κB repressing factorNKRF−2
    NM_005904SMAD family member 7SMAD7−3.08
    NM_021643Tribbles homolog 2 (Drosophila)TRIB2−2.77
    NM_000692Aldehyde dehydrogenase 1 family, member B1ALDH1B1−2.39
    AI861942Low-density lipoprotein receptorLDLR−2.01
    AL520774Malate dehydrogenase 2, NAD (mitochondrial)MDH2−2.02
    BC002715Peroxisome proliferator-activated receptor δPPARD−2.06
    U89386Platelet-activating factor acetylhydrolase 2PAFAH2−2.1
Transcription factors
    NM_005982Sine oculis homeobox homolog 1 (Drosophila)SIX1−3.31
    AI382146SRY (sex determining region Y)-box 9SOX9−3.06
    BC001161Zinc finger protein 174ZNF174−2.11
    NM_006991Zinc finger protein 197ZNF197−2.47
    AU151157Zinc finger protein 783ZNF783−2.6
Ion metabolism
    NM_005199Cholinergic receptor, nicotinic, gammaCHRNG−2.05
Protein binding
    NM_006472Thioredoxin interacting proteinTXNIP−2.88
  • Genes shown to be downregulated in astrocytes by lipolysis product treatment are classified functionally into apoptosis/cell cycle, inflammatory responses, metabolism, transcription factors, ion metabolism, and protein binding classes.