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![]() [Cover Caption] Other Issues: |
Contents: Volume 278, Issue 1
January 2000 [Index by Author]
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Cover: Ca2+ sparks activate
Ca2+-sensitive K+ (BKCa) channel
currents in smooth muscle cells from cerebral arteries. Top:
original sequence (from left to right) of 2-dimensional
confocal images obtained every 8.33 ms of an isolated cerebral artery
smooth muscle cell loaded with the Ca2+-sensitive
fluorescent dye fluo 3. Two Ca2+ spark sites were
identified as indicated by the green and red (2.2 × 2.2 mm) boxes. A
Ca2+ spark begins in the red box in the 2nd image.
Middle: simultaneous BKCa channel currents and
Ca2+ sparks at
40 mV, illustrating temporal association.
Membrane current (blue trace) is indicated above the
fluorescence (F/F0) averages of the red and green boxes
indicated at top, respectively. Bottom: subsequent
images of the region of interest at top (dotted box),
illustrating the time course of the rise, decay, and spread of the
Ca2+ spark. (Modified from Perez et al. J. Gen.
Physiol. 113: 229-238, 1999.) See related article by J. H. Jaggar,
V. A. Porter, W. J. Lederer, and M. T. Nelson. Am. J. Physiol. Cell
Physiol. 278:C235-C255, 2000.
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