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RECEPTORS AND SIGNAL TRANSDUCTION

Human breast milk suppresses the transcriptional regulation of IL-1-induced NF-B signaling in human intestinal cells

¹Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka 565-0871; and ²Department of Gynecology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan

Submitted 29 October 2003 ; accepted in final form 26 June 2004

Neonatal necrotizing enterocolitis (NEC), which is a disease with a poor prognosis, is considered to be caused by the coincidence of intestinal ischemia-reperfusion injury and systemic inflammation due to the colonization of pathogenic bacteria. Interleukin (IL)-8, a proinflammatory cytokine, plays an important role in the pathophysiology of NEC. It was recently reported that IL-1 activates the IL-8 gene by regulating the transcriptional nuclear factor B (NF-B) signaling pathways in intestinal cells. The protective role of maternal milk in NEC pathogenesis has been reported in both human and animal studies. In this study, we show that human breast milk dramatically suppressed the IL-1-induced activation of the IL-8 gene promoter by inhibiting the activation pathway of NF-B. Moreover, we also show that human breast milk induced the production of IB. These results suggest that human breast milk could be protective and therapeutic in neonates with NEC by inhibiting the activation pathway of NF-B.

interleukin-8

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