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Am J Physiol Cell Physiol 286: C239-C246, 2004. First published October 8, 2003; doi:10.1152/ajpcell.00036.2003
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VASCULAR BIOLOGY

Stimulation of adhesion molecule expression in human endothelial cells (HUVEC) by adrenomedullin and corticotrophin

Eleni Hagi-Pavli, Paula M. Farthing, and Supriya Kapas

Molecular Signalling Group, Clinical Science Research Centre, Barts & the London, Queen Mary, University of London, London E1 2AD, United Kingdom

Submitted 23 January 2003 ; accepted in final form 20 August 2003

Adrenomedullin (AM) and corticotrophin (ACTH) are both vasoactive peptides produced by a variety of cell types, including endothelial cells. Although AM and ACTH are considered to be important in the control of blood pressure and the response to stress, respectively, their role in inflammation and the immune response has not been clarified. This study shows, with the use of a cell-based ELISA, that AM and ACTH induce cell surface expression of the adhesion molecules E-selectin, VCAM-1, and ICAM-1 on human umbilical vein endothelial cells (HUVEC). Furthermore, this effect appears to be mediated in part via elevation of cAMP, given that both peptides elevate cAMP, the cell-permeable cAMP analog dibutyryl cAMP is able to mimic induction of all three cell adhesion molecules and the effect of AM and ACTH is inhibited by the adenylyl cyclase inhibitor SQ-22536. These findings demonstrate a role for AM and ACTH in the regulation of the immune and inflammatory response.

E-selectin; intercellular adhesion molecule-1; vascular cell adhesion molecule-1; adrenomedullin; adrenocorticotropic hormone; human umbilical vein endothelial cells


Address for reprint requests and other correspondence: P. M. Farthing, Molecular Signalling Group, Clinical Science Research Centre, Barts & the London Queen Mary Univ. of London, 2 Newark St., London E1 2AD, UK (E-mail: p.m.farthing{at}qmul.ac.uk).




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