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Am J Physiol Cell Physiol 270: C711-C730, 1996;
0363-6143/96 $5.00
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AJP - Cell Physiology, Vol 270, Issue 3 C711-C730, Copyright © 1996 by American Physiological Society

ARTICLES

Cellular and molecular physiology of volume-sensitive anion channels

K. Strange, F. Emma and P. S. Jackson
Critical Care Research Laboratories, Department of Medicine, Childrens Hospital, Boston, Massachusetts 02115, USA.

Maintenance of a constant cell volume in the face of osmotic stress is an evolutionarily ancient homeostatic process. Over the last two decades physiologists have gained an impressive understanding of the "volume-sensitive" channels, cotransporters, exchangers, metabolic pathways, and genes that are responsible for modulating intracellular solute content and cell volume. This review focuses on one part of this story, the characteristics and osmoregulatory functions of volume-sensitive anion channels. Three distinct types of swelling-activated anion channels have been observed and studied extensively in animal cells. These channels include 1) ClC-2, which is a member of the ClC family of voltage-gated anion channels, 2) an outwardly rectifying intermediate conductance channel, and 3) a large-conductance or "maxi" channel. In addition to these three channels, several other less well-characterized anion channels have been observed. This review discusses the electrophysiological and molecular biological characteristics and regulation of these channels. The possible roles different types of anion channels might play in cell volume homeostasis are also discussed.


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H. Guizouarn and R. Motais
Swelling activation of transport pathways in erythrocytes: effects of Cl-, ionic strength, and volume changes
Am J Physiol Cell Physiol, January 1, 1999; 276(1): C210 - C220.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
I. A. Greenwood and W. A. Large
Properties of a Cl- current activated by cell swelling in rabbit portal vein vascular smooth muscle cells
Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1524 - H1532.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
C. Eder, R. Klee, and U. Heinemann
Involvement of Stretch-Activated Cl- Channels in Ramification of Murine Microglia
J. Neurosci., September 15, 1998; 18(18): 7127 - 7137.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
G. Droogmans, J. Prenen, J. Eggermont, T. Voets, and B. Nilius
Voltage-dependent block of endothelial volume-regulated anion channels by calix[4]arenes
Am J Physiol Cell Physiol, September 1, 1998; 275(3): C646 - C652.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
R. W. Freel, M. Hatch, and N. D. Vaziri
Conductive pathways for chloride and oxalate in rabbit ileal brush-border membrane vesicles
Am J Physiol Cell Physiol, September 1, 1998; 275(3): C748 - C757.
[Abstract] [Full Text] [PDF]

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 BloodHome page
C.-J. C. Tang and T. K. Tang
The 30-kD Domain of Protein 4.1 Mediates Its Binding to the Carboxyl Terminus of pICln, a Protein Involved in Cellular Volume Regulation
Blood, August 15, 1998; 92(4): 1442 - 1447.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
C. L. Cannon, S. Basavappa, and K. Strange
Intracellular ionic strength regulates the volume sensitivity of a swelling-activated anion channel
Am J Physiol Cell Physiol, August 1, 1998; 275(2): C416 - C422.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
S. M. Huber and M. F. Horster
Expression of a hypotonic swelling-activated Cl conductance during ontogeny of collecting duct epithelium
Am J Physiol Renal Physiol, July 1, 1998; 275(1): F25 - F32.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
C. H. Mitchell, D. A. Carre, A. M. McGlinn, R. A. Stone, and M. M. Civan
A release mechanism for stored ATP in ocular ciliary epithelial cells
PNAS, June 9, 1998; 95(12): 7174 - 7178.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
E. M. Rutledge, M. Aschner, and H. K. Kimelberg
Pharmacological characterization of swelling-induced D-[3H]aspartate release from primary astrocyte cultures
Am J Physiol Cell Physiol, June 1, 1998; 274(6): C1511 - C1520.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
F. Emma, S. Breton, R. Morrison, S. Wright, and K. Strange
Effect of cell swelling on membrane and cytoplasmic distribution of pICln
Am J Physiol Cell Physiol, June 1, 1998; 274(6): C1545 - C1551.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
B. M. Tulk and J. C. Edwards
NCC27, a homolog of intracellular Cl- channel p64, is expressed in brush border of renal proximal tubule
Am J Physiol Renal Physiol, June 1, 1998; 274(6): F1140 - F1149.
[Abstract] [Full Text] [PDF]

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 FASEB J.Home page
J.-H. Park, M. R. Edwards, and P. J. Schofield
Swelling detection for volume regulation in the primitive eukaryote Giardia intestinalis: a common feature of volume detection in present-day eukaryotes
FASEB J, May 1, 1998; 12(7): 571 - 579.
[Abstract] [Full Text]

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 J. Neurosci.Home page
A. J. Patel, I. Lauritzen, M. Lazdunski, and E. Honore
Disruption of Mitochondrial Respiration Inhibits Volume-Regulated Anion Channels and Provokes Neuronal Cell Swelling
J. Neurosci., May 1, 1998; 18(9): 3117 - 3123.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Renal Physiol.Home page
S. Huber, B. Schroppel, M. Kretzler, D. Schlondorff, and M. Horster
Single cell RT-PCR analysis of ClC-2 mRNA expression in ureteric bud tip
Am J Physiol Renal Physiol, May 1, 1998; 274(5): F951 - F957.
[Abstract] [Full Text] [PDF]

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 J. Neurophysiol.Home page
S. Basavappa, S. F. Pedersen, N. K. Jorgensen, J. C. Ellory, and E. K. Hoffmann
Swelling-Induced Arachidonic Acid Release via the 85-kDa cPLA2 in Human Neuroblastoma Cells
J Neurophysiol, March 1, 1998; 79(3): 1441 - 1449.
[Abstract] [Full Text] [PDF]

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 J. Neurosci.Home page
V. Crepel, W. Panenka, M. E. M. Kelly, and B. A. MacVicar
Mitogen-Activated Protein and Tyrosine Kinases in the Activation of Astrocyte Volume-Activated Chloride Current
J. Neurosci., February 15, 1998; 18(4): 1196 - 1206.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. S. Monaghan, G. M. Mintenig, and F. V. Sepulveda
Outwardly rectifying Cl- channel in guinea pig small intestinal villus enterocytes: effect of inhibitors
Am J Physiol Gastrointest Liver Physiol, November 1, 1997; 273(5): G1141 - G1152.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. D. Lidofsky and R. M. Roman
Alanine uptake activates hepatocellular chloride channels
Am J Physiol Gastrointest Liver Physiol, October 1, 1997; 273(4): G849 - G853.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
J. Yamazaki and J. R. Hume
Inhibitory Effects of Glibenclamide on Cystic Fibrosis Transmembrane Regulator, Swelling-Activated, and Ca2+-Activated Cl- Channels in Mammalian Cardiac Myocytes
Circ. Res., July 19, 1997; 81(1): 101 - 109.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
E. Krump, K. Nikitas, and S. Grinstein
Induction of Tyrosine Phosphorylation and Na+/H+ Exchanger Activation during Shrinkage of Human Neutrophils
J. Biol. Chem., July 11, 1997; 272(28): 17303 - 17311.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
G. Buyse, T. Voets, J. Tytgat, C. De Greef, G. Droogmans, B. Nilius, and J. Eggermont
Expression of Human pICln and ClC-6 in Xenopus Oocytes Induces an Identical Endogenous Chloride Conductance
J. Biol. Chem., February 7, 1997; 272(6): 3615 - 3621.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
H. Lock and M. A. Valverde
Contribution of the IsK (MinK) Potassium Channel Subunit to Regulatory Volume Decrease in Murine Tracheal Epithelial Cells
J. Biol. Chem., November 3, 2000; 275(45): 34849 - 34852.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
X. Li, K. Shimada, L. A. Showalter, and S. A. Weinman
Biophysical Properties of ClC-3 Differentiate It from Swelling-activated Chloride Channels in Chinese Hamster Ovary-K1 Cells
J. Biol. Chem., November 10, 2000; 275(46): 35994 - 35998.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
K.-H. Weylandt, M. A. Valverde, M. Nobles, S. Raguz, J. S. Amey, M. Diaz, C. Nastrucci, C. F. Higgins, and A. Sardini
Human ClC-3 Is Not the Swelling-activated Chloride Channel Involved in Cell Volume Regulation
J. Biol. Chem., May 11, 2001; 276(20): 17461 - 17467.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. Christensen and K. Strange
Developmental Regulation of a Novel Outwardly Rectifying Mechanosensitive Anion Channel in Caenorhabditis elegans
J. Biol. Chem., November 21, 2001; 276(48): 45024 - 45030.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. J. Harrop, M. Z. DeMaere, W. D. Fairlie, T. Reztsova, S. M. Valenzuela, M. Mazzanti, R. Tonini, M. R. Qiu, L. Jankova, K. Warton, et al.
Crystal Structure of a Soluble Form of the Intracellular Chloride Ion Channel CLIC1 (NCC27) at 1.4-A Resolution
J. Biol. Chem., November 21, 2001; 276(48): 44993 - 45000.
[Abstract] [Full Text] [PDF]


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