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Am J Physiol Cell Physiol 266: C1485-C1504, 1994;
0363-6143/94 $5.00
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AJP - Cell Physiology, Vol 266, Issue 6 C1485-C1504, Copyright © 1994 by American Physiological Society

ARTICLES

Structure and function of ryanodine receptors

R. Coronado, J. Morrissette, M. Sukhareva and D. M. Vaughan
Department of Physiology, University of Wisconsin School of Medicine, Madison 53706.

Membrane depolarization, neurotransmitters, and hormones evoke a release of Ca2+ from intracellular Ca(2+)-storing organelles like the endoplasmic reticulum and, in muscle, the sarcoplasmic reticulum (SR). In turn, the released Ca2+ serves to trigger a variety of cellular responses. The presence of Ca2+ pumps to replenish intracellular stores was described more than 20 years ago. The presence of Ca2+ channels, like the ryanodine receptor, which suddenly release the organelle-stored Ca2+, is a more recent finding. This review describes the progress made in the last five years on the structure, function, and regulation of the ryanodine receptor. Numerous reports have described the response of ryanodine receptors to cellular ions and metabolites, kinases and other proteins, and pharmacological agents. In many cases, comparative measurements have been made using Ca2+ fluxes in SR vesicles, single-channel recordings in planar bilayers, and radioligand binding assays using [3H]ryanodine. These techniques have helped to relate the activity of single ryanodine receptors to global changes in the SR Ca2+ permeability. Molecular information on functional domains within the primary structure of the ryanodine receptor is also available. There are at least three ryanodine receptor isoforms in various tissues. Some cells, such as amphibian muscle cells, express more than a single isoform. The diversity of ligands known to modulate gating and the diversity of tissues known to express the protein suggest that the ryanodine receptor has the potential to participate in many types of cell stimulus-Ca(2+)-release coupling mechanisms.


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[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
L. Snajdrova, A. Xu, and N. Narayanan
Clotrimazole, an Antimycotic Drug, Inhibits the Sarcoplasmic Reticulum Calcium Pump and Contractile Function in Heart Muscle
J. Biol. Chem., October 23, 1998; 273(43): 28032 - 28039.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Jiang and F. J. Julian
Effects of isoflurane on [Ca2+]i, SR Ca2+ content, and twitch force in intact trabeculae
Am J Physiol Heart Circ Physiol, October 1, 1998; 275(4): H1360 - H1369.
[Abstract] [Full Text] [PDF]

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M. B. Meyers, T. S. Puri, A. J. Chien, T. Gao, P.-H. Hsu, M. M. Hosey, and G. I. Fishman
Sorcin Associates with the Pore-forming Subunit of Voltage-dependent L-type Ca2+ Channels
J. Biol. Chem., July 24, 1998; 273(30): 18930 - 18935.
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L. H. Jeyakumar, J. A. Copello, A. M. O'Malley, G.-M. Wu, R. Grassucci, T. Wagenknecht, and S. Fleischer
Purification and Characterization of Ryanodine Receptor 3 from Mammalian Tissue
J. Biol. Chem., June 26, 1998; 273(26): 16011 - 16020.
[Abstract] [Full Text] [PDF]

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S. R. W. Chen, K. Ebisawa, X. Li, and L. Zhang
Molecular Identification of the Ryanodine Receptor Ca2+ Sensor
J. Biol. Chem., June 12, 1998; 273(24): 14675 - 14678.
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K. R. Bidasee and H. R. Besch Jr.
Structure-Function Relationships among Ryanodine Derivatives. PYRIDYL RYANODINE DEFINITIVELY SEPARATES ACTIVATION POTENCY FROM HIGH AFFINITY
J. Biol. Chem., May 15, 1998; 273(20): 12176 - 12186.
[Abstract] [Full Text] [PDF]

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B. Aguado and R. D. Campbell
Characterization of a Human Lysophosphatidic Acid Acyltransferase That Is Encoded by a Gene Located in the Class III Region of the Human Major Histocompatibility Complex
J. Biol. Chem., February 13, 1998; 273(7): 4096 - 4105.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
C. F. Perez, J. J. Marengo, R. Bull, and C. Hidalgo
Cyclic ADP-ribose activates caffeine-sensitive calcium channels from sea urchin egg microsomes
Am J Physiol Cell Physiol, February 1, 1998; 274(2): C430 - C439.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
W. Liu, D. A. Pasek, and G. Meissner
Modulation of Ca2+-gated cardiac muscle Ca2+-release channel (ryanodine receptor) by mono- and divalent ions
Am J Physiol Cell Physiol, January 1, 1998; 274(1): C120 - C128.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Heart Circ. Physiol.Home page
D. L. Jones and N. Narayanan
Defibrillation depresses heart sarcoplasmic reticulum calcium pump: a mechanism of postshock dysfunction
Am J Physiol Heart Circ Physiol, January 1, 1998; 274(1): H98 - H105.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. J. Fitzsimmons, J. A. McRoberts, K. H. Tachiki, and S. J. Pandol
Acyl-Coenzyme A Causes Ca2+ Release in Pancreatic Acinar Cells
J. Biol. Chem., December 12, 1997; 272(50): 31435 - 31440.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Cell Physiol.Home page
X. Zhang, J. Wen, K. R. Bidasee, H. R. Besch Jr., and R. P. Rubin
Ryanodine receptor expression is associated with intracellular Ca2+ release in rat parotid acinar cells
Am J Physiol Cell Physiol, October 1, 1997; 273(4): C1306 - C1314.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
S. R. W. Chen, X. Li, K. Ebisawa, and L. Zhang
Functional Characterization of the Recombinant Type 3 Ca2+ Release Channel (Ryanodine Receptor) Expressed in HEK293 Cells
J. Biol. Chem., September 26, 1997; 272(39): 24234 - 24246.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. Murayama and Y. Ogawa
Characterization of Type 3 Ryanodine Receptor (RyR3) of Sarcoplasmic Reticulum from Rabbit Skeletal Muscles
J. Biol. Chem., September 19, 1997; 272(38): 24030 - 24037.
[Abstract] [Full Text] [PDF]

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 J. Pharmacol. Exp. Ther.Home page
R. T. Sudo and T. E. Nelson
Changes in Ryanodine-Induced Contractures by Stimulus Frequency in Malignant Hyperthermia Susceptible and Malignant Hyperthermia Nonsusceptible Dog Skeletal Muscle
J. Pharmacol. Exp. Ther., September 1, 1997; 282(3): 1331 - 1336.
[Abstract] [Full Text]

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P. Tarroni, D. Rossi, A. Conti, and V. Sorrentino
Expression of the Ryanodine Receptor Type 3 Calcium Release Channel during Development and Differentiation of Mammalian Skeletal Muscle Cells
J. Biol. Chem., August 8, 1997; 272(32): 19808 - 19813.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
D. H. DiJulio, E. L. Watson, I. N. Pessah, K. L. Jacobson, S. M. Ott, E. D. Buck, and J. C. Singh
Ryanodine Receptor Type III (Ry3R) Identification In Mouse Parotid Acini. PROPERTIES AND MODULATION OF [3H]RYANODINE-BINDING SITES
J. Biol. Chem., June 20, 1997; 272(25): 15687 - 15696.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
P. W. Wong, W. R. Brackney, and I. N. Pessah
ortho-Substituted Polychlorinated Biphenyls Alter Microsomal Calcium Transport by Direct Interaction with Ryanodine Receptors of Mammalian Brain
J. Biol. Chem., June 13, 1997; 272(24): 15145 - 15153.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
E. D. Buck, H. T. Nguyen, I. N. Pessah, and P. D. Allen
Dyspedic Mouse Skeletal Muscle Expresses Major Elements of the Triadic Junction but Lacks Detectable Ryanodine Receptor Protein and Function
J. Biol. Chem., March 14, 1997; 272(11): 7360 - 7367.
[Abstract] [Full Text] [PDF]

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 Pharmacol. Rev.Home page
R. Zucchi and S. Ronca-Testoni
The Sarcoplasmic Reticulum Ca2+ Channel/Ryanodine Receptor: Modulation by Endogenous Effectors, Drugs and Disease States
Pharmacol. Rev., March 1, 1997; 49(1): 1 - 52.
[Abstract] [Full Text] [PDF]

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 Pharmacol. Rev.Home page
J. L. Sutko, J. A. Airey, W. Welch, and L. Ruest
The Pharmacology of Ryanodine and Related Compounds
Pharmacol. Rev., March 1, 1997; 49(1): 53 - 98.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. Richter, L. Schleithoff, T. Deufel, F. Lehmann-Horn, and A. Herrmann-Frank
Functional Characterization of a Distinct Ryanodine Receptor Mutation in Human Malignant Hyperthermia-susceptible Muscle
J. Biol. Chem., February 21, 1997; 272(8): 5256 - 5260.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
G. Meissner, E. Rios, A. Tripathy, and D. A. Pasek
Regulation of Skeletal Muscle Ca2+ Release Channel (Ryanodine Receptor) by Ca2+ and Monovalent Cations and Anions
J. Biol. Chem., January 17, 1997; 272(3): 1628 - 1638.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
L. Xu, G. Mann, and G. Meissner
Regulation of Cardiac Ca2+ Release Channel (Ryanodine Receptor) by Ca2+, H+, Mg2+, and Adenine Nucleotides Under Normal and Simulated Ischemic Conditions
Circ. Res., December 1, 1996; 79(6): 1100 - 1109.
[Abstract] [Full Text]

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 Circ. Res.Home page
E. Kaftan, A. R. Marks, and B. E. Ehrlich
Effects of Rapamycin on Ryanodine Receptor/Ca2+-Release Channels From Cardiac Muscle
Circ. Res., June 1, 1996; 78(6): 990 - 997.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
N. Yamaguchi, C. Xin, and G. Meissner
Identification of Apocalmodulin and Ca2+-Calmodulin Regulatory Domain in Skeletal Muscle Ca2+ Release Channel, Ryanodine Receptor
J. Biol. Chem., June 15, 2001; 276(25): 22579 - 22585.
[Abstract] [Full Text] [PDF]

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 Proc. Natl. Acad. Sci. USAHome page
G. G. Du, X. Guo, V. K. Khanna, and D. H. MacLennan
Ryanodine sensitizes the cardiac Ca2+ release channel (ryanodine receptor isoform 2) to Ca2+ activation and dissociates as the channel is closed by Ca2+ depletion
PNAS, November 20, 2001; 98(24): 13625 - 13630.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
V. Lukyanenko, I. Gyorke, T. F. Wiesner, and S. Gyorke
Potentiation of Ca2+ Release by cADP-Ribose in the Heart Is Mediated by Enhanced SR Ca2+ Uptake Into the Sarcoplasmic Reticulum
Circ. Res., September 28, 2001; 89(7): 614 - 622.
[Abstract] [Full Text] [PDF]


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