Submitted on October 9, 2008
Revised on February 23, 2009
Accepted on February 23, 2009
The eIF4E binding proteins (4E-BPs) are modifiers of eIF4E relocalization during the heat shock response
Rami Sukarieh1, Nahum Sonenberg1, and Jerry Pelletier1*
1 McGill University
* To whom correspondence should be addressed. E-mail: jerry.pelletier{at}mcgill.ca.
Stress granules (SGs) arise as a consequence of cellular stress, contain stalled translation preinitiation complexes, and are associated with cell survival during environmental insults. SGs are dynamic entities with proteins relocating into and out of them during stress. Among the repertoire of proteins present in SGs is eIF4E, a translation factor required for cap-dependent translation and which regulates a rate-limiting step for protein synthesis. Herein, we demonstrate that localization of eIF4E to SGs is dependent on the presence of a family of repressor proteins, eIF4E-binding proteins (4E-BPs). Our results demonstrate that 4E-BPs regulate SG localization of eIF4E.
