Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol (December 5, 2001). doi:10.1152/ajpcell.00483.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/5/C984    most recent
00483.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mitchell, P. O
Right arrow Articles by Pavlath, G. K
Right arrow Search for Related Content
PubMed
Right arrow Articles by Mitchell, P. O
Right arrow Articles by Pavlath, G. K

Articles in PresS, published online ahead of print December 5, 2001
Am J Physiol Cell Physiol, 10.1152/ajpcell.00483.2001
Submitted on October 10, 2001
Accepted on December 3, 2001

Calcineurin differentially regulates maintenance and growth of phenotypically distinct muscles

Patrick O Mitchell1, Stephen T Mills1, and Grace K Pavlath1*

1 Pharmacology, Emory University, Atlanta, GA, USA

* To whom correspondence should be addressed. E-mail: gpavlath{at}bimcore.emory.edu.

Adequate muscle mass is critical for human health. The molecular pathways regulating maintenance and growth of adult skeletal muscle are little understood. Calcineurin (CN) is implicated as a key signaling molecule in hypertrophy. Whether CN is involved in all forms of muscle growth or in different muscles is unknown. Here, we examine the role of CN in regulating maintenance of muscle size and growth of atrophied muscle in the soleus (slow) and plantaris (fast). The CN inhibitor, cyclosporine A (CsA) differentially affects muscle growth and maintenance depending on muscle phenotype. The plantaris is more severely affected by CsA than the soleus in both growth conditions. One week vs two week CsA treatment suggests that both CN dependent and independent growth occur in the atrophied soleus, whereas plantaris growth appears to be totally CN dependent. Our results suggest that CN regulates multiple types of muscle growth depending both on muscle phenotype and stage of myofiber growth. Differential expression of components of the CN pathway occurs and may contribute to the differences between muscles.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
R. S. O'Connor and G. K. Pavlath
Point:Counterpoint: Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy
J Appl Physiol, September 1, 2007; 103(3): 1099 - 1100.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Stupka, J. D. Schertzer, R. Bassel-Duby, E. N. Olson, and G. S. Lynch
Calcineurin-A{alpha} activation enhances the structure and function of regenerating muscles after myotoxic injury
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R686 - R694.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
K. Eizema, D. E. van der Wal, M. M.M. van den Burg, H. W. de Jonge, and M. E. Everts
Differential Expression of Calcineurin and SR Ca2+ Handling Proteins in Equine Muscle Fibers During Early Postnatal Growth
J. Histochem. Cytochem., March 1, 2007; 55(3): 247 - 254.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
P. Pregelj, M. Trinkaus, D. Zupan, J. J. Trontelj, and J. Sketelj
The Role of Muscle Activation Pattern and Calcineurin in Acetylcholinesterase Regulation in Rat Skeletal Muscles
J. Neurosci., January 31, 2007; 27(5): 1106 - 1113.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
H. W. de Jonge, C. W. van der Wiel, K. Eizema, W. A. Weijs, and M. E. Everts
Presence of SERCA and Calcineurin during Fetal Development of Porcine Skeletal Muscle
J. Histochem. Cytochem., June 1, 2006; 54(6): 641 - 648.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
B. A. Bondesen, S. T. Mills, and G. K. Pavlath
The COX-2 pathway regulates growth of atrophied muscle via multiple mechanisms
Am J Physiol Cell Physiol, June 1, 2006; 290(6): C1651 - C1659.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. G. Tidball
Mechanical signal transduction in skeletal muscle growth and adaptation
J Appl Physiol, May 1, 2005; 98(5): 1900 - 1908.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Sugiura, N. Abe, M. Nagano, K. Goto, K. Sakuma, H. Naito, T. Yoshioka, and S. K. Powers
Changes in PKB/Akt and calcineurin signaling during recovery in atrophied soleus muscle induced by unloading
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1273 - R1278.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Parsons, D. P. Millay, B. J. Wilkins, O. F. Bueno, G. L. Tsika, J. R. Neilson, C. M. Liberatore, K. E. Yutzey, G. R. Crabtree, R. W. Tsika, et al.
Genetic Loss of Calcineurin Blocks Mechanical Overload-induced Skeletal Muscle Fiber Type Switching but Not Hypertrophy
J. Biol. Chem., June 18, 2004; 279(25): 26192 - 26200.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. Tashiro, L. C. Samuelson, R. A. Liddle, and J. A. Williams
Calcineurin mediates pancreatic growth in protease inhibitor-treated mice
Am J Physiol Gastrointest Liver Physiol, May 1, 2004; 286(5): G784 - G790.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. E. Childs, E. E. Spangenburg, D. R. Vyas, and F. W. Booth
Temporal alterations in protein signaling cascades during recovery from muscle atrophy
Am J Physiol Cell Physiol, August 1, 2003; 285(2): C391 - C398.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
S. A. Parsons, B. J. Wilkins, O. F. Bueno, and J. D. Molkentin
Altered Skeletal Muscle Phenotypes in Calcineurin A{alpha} and A{beta} Gene-Targeted Mice
Mol. Cell. Biol., June 15, 2003; 23(12): 4331 - 4343.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
V. Horsley and G. K. Pavlath
Prostaglandin F2{alpha} stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway
J. Cell Biol., April 14, 2003; 161(1): 111 - 118.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.