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Am J Physiol Cell Physiol (November 27, 2002). doi:10.1152/ajpcell.00465.2002
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Articles in PresS, published online ahead of print November 27, 2002
Am J Physiol Cell Physiol, 10.1152/ajpcell.00465.2002
Submitted on October 3, 2002
Accepted on November 22, 2002

Alterations in Ca2+ Cycling by Lysoplasmenylcholine in Adult Rabbit Ventricular Myocytes

Shi J Liu1*, Richard H Kennedy1, Michael H Creer2, and Jane McHowat2

1 Pharmaceutical Sciences, Univeristy of Arkansas for Medical Sciences, Little Rock, AR, USA; Pharmacology &Toxicology, Univeristy of Arkansas for Medical Sciences, Little Rock, AR, USA
2 Pathology, Saint Louis University Medical School, St. Louis, MO, USA

* To whom correspondence should be addressed. E-mail: liushi{at}uams.edu.

We previously reported that lysoplasmenylcholine (LPlasC) altered the action potential (AP) and induced afterdepolarizations in rabbit ventricular myocytes. In this study, we investigated how LPlasC alters excitation-contraction coupling using edge-motion detecting, Fura-PE3 fluorescent indicator, and perforated and whole-cell patch-clamp techniques. LPlasC increased contraction, myofilament Ca2+ sensitivity, systolic and diastolic free Ca2+ levels, and the magnitude of Ca2+ transients concomitant with increases in the maximum rates of shortening and relaxation of contraction, and the rising and declining phases of Ca2+ transients. In some cells, LPlasC induced arrhythmias in a pattern consistent with early and delayed aftercontractions. LPlasC also augmented the caffeine-induced Ca2+ transient with a reduction in its decay rate. Furthermore, LPlasC enhanced ICa,L and outward currents. LPlasC-induced alterations in contraction and ICa,L were paralleled by its effect on the AP. Thus, these results suggest that LPlasC elicits distinct, potent positive inotropic, lusitropic and arrhythmogenic effects, resulting from increases in Ca2+ influx, Ca2+ sensitivity, sarcoplasmic reticular (SR) Ca2+ release and uptake, SR Ca2+ content and probably reduction in sarcolemmal Na+/Ca2+ exchange.




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