Am J Physiol Cell Physiol Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol (April 23, 2003). doi:10.1152/ajpcell.00453.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/2/C370    most recent
00453.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Li, Y.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Li, Y.-P.
Submitted on September 30, 2002
Accepted on April 16, 2003

TNF-{alpha} is a mitogen in skeletal muscle

Yi-Ping Li1*

1 Department of Medicine, Baylor College of Medicine, Houston, TX, USA

* To whom correspondence should be addressed. E-mail: yiping{at}bcm.tmc.edu.

Emerging evidence suggests that tumor necrosis factor-{alpha} (TNF-{alpha}) plays a role in muscle repair. To determine whether TNF-{alpha} modulates satellite cell proliferation, the current study evaluated TNF-{alpha} effects on DNA synthesis in primary myoblasts and on satellite cell activation in adult mouse muscle. Exposure to recombinant TNF-{alpha} increased total DNA content in rat primary myoblasts dose-dependently over a 24 hr period, and the number of primary myoblasts incorporating 5-bromo-2'-deoxyuridine (BrdU) during a 30 min pulse labeling. Systemic injection of TNF-{alpha} stimulated BrdU incorporation by satellite cells in muscles of adult mice, while no BrdU was incorporated by satellite cells in control mice. TNF-{alpha} stimulated serum response factor (SRF) binding to the serum response element (SRE) present in the c-fos gene promoter, and reporter gene expression controlled by the same element. Our data suggest that TNF-{alpha} activates satellite cells to enter the cell cycle and accelerates G1 to S phase transition, and these actions may involve activation of early response genes via SRF.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
U. R. Mikkelsen, H. Langberg, I. C. Helmark, D. Skovgaard, L. L. Andersen, M. Kjaer, and A. L. Mackey
Local NSAID infusion inhibits satellite cell proliferation in human skeletal muscle after eccentric exercise
J Appl Physiol, November 1, 2009; 107(5): 1600 - 1611.
[Abstract] [Full Text] [PDF]

Home page
 In VivoHome page
M. KARALAKI, S. FILI, A. PHILIPPOU, and M. KOUTSILIERIS
Muscle Regeneration: Cellular and Molecular Events
In Vivo, September 1, 2009; 23(5): 779 - 796.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
E Barreiro, A M W J Schols, M I Polkey, J B Galdiz, H R Gosker, E B Swallow, C Coronell, J Gea, and on behalf of the ENIGMA in COPD project
Cytokine profile in quadriceps muscles of patients with severe COPD
Thorax, February 1, 2008; 63(2): 100 - 107.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Arnold, A. Henry, F. Poron, Y. Baba-Amer, N. van Rooijen, A. Plonquet, R. K. Gherardi, and B. Chazaud
Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
J. Exp. Med., May 14, 2007; 204(5): 1057 - 1069.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S.-E. Chen, B. Jin, and Y.-P. Li
TNF-{alpha} regulates myogenesis and muscle regeneration by activating p38 MAPK
Am J Physiol Cell Physiol, May 1, 2007; 292(5): C1660 - C1671.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Vassilakopoulos and S. N. A. Hussain
Ventilatory muscle activation and inflammation: cytokines, reactive oxygen species, and nitric oxide
J Appl Physiol, April 1, 2007; 102(4): 1687 - 1695.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. Zhan, B. Jin, S.-E. Chen, J. M. Reecy, and Y.-P. Li
TACE release of TNF-{alpha} mediates mechanotransduction-induced activation of p38 MAPK and myogenesis
J. Cell Sci., February 15, 2007; 120(4): 692 - 701.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
Y. Nagata, T. A. Partridge, R. Matsuda, and P. S. Zammit
Entry of muscle satellite cells into the cell cycle requires sphingolipid signaling
J. Cell Biol., July 17, 2006; 174(2): 245 - 253.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
X. Shi and D. J. Garry
Muscle stem cells in development, regeneration, and disease.
Genes & Dev., July 1, 2006; 20(13): 1692 - 1708.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
N. C. Jones, K. J. Tyner, L. Nibarger, H. M. Stanley, D. D.W. Cornelison, Y. V. Fedorov, and B. B. Olwin
The p38{alpha}/{beta} MAPK functions as a molecular switch to activate the quiescent satellite cell
J. Cell Biol., April 11, 2005; 169(1): 105 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
S. N. Mehiri, E. Barreiro, M. Hayot, M. Voyer, A. S. Comtois, A. E. Grassino, and G. Czaika
Time-based gene expression programme following diaphragm injury in a rat model
Eur. Respir. J., March 1, 2005; 25(3): 422 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Vassilakopoulos, C. Roussos, and S. Zakynthinos
The immune response to resistive breathing
Eur. Respir. J., December 1, 2004; 24(6): 1033 - 1043.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Vassilakopoulos, M. Divangahi, G. Rallis, O. Kishta, B. Petrof, A. Comtois, and S. N. A. Hussain
Differential Cytokine Gene Expression in the Diaphragm in Response to Strenuous Resistive Breathing
Am. J. Respir. Crit. Care Med., July 15, 2004; 170(2): 154 - 161.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.