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Am J Physiol Cell Physiol (December 12, 2001). doi:10.1152/ajpcell.00372.2001
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Articles in PresS, published online ahead of print December 12, 2001
Am J Physiol Cell Physiol, 10.1152/ajpcell.00372.2001
Submitted on August 3, 2001
Accepted on December 6, 2001

Myostatin is an inhibitor of myogenic differentiation

Ramon Rios1*, Isabel Carneiro1, Victor M Arce1, and Jesus Devesa1

1 Physiology, University of Santiago de Compostela School of Medicine, Santiago, A Coruna, Spain

* To whom correspondence should be addressed. E-mail: fsrrios{at}usc.es.

Myostatin (MSTN), a TGF-ß superfamily member, has been shown to negatively regulate muscle growth by inhibiting muscle precursor cells proliferation. Here, we stably transfected C2C12 cells with mouse MSTN cDNA to investigate its possible role in myoblast differentiation. We found that MSTN cDNA overexpression inhibits the myogenic process by downregulating mRNA levels of the muscle regulatory factors myoD and myogenin, as well as the activity of their downstream target creatine kinase. Taking into consideration that MSTN expression during development is restricted to muscle, our results suggest that MSTN probably regulates myogenic differentiation by an autocrine mechanism.




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