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Am J Physiol Cell Physiol (November 21, 2001). doi:10.1152/ajpcell.00239.2001
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Articles in PresS, published online ahead of print November 20, 2001
Am J Physiol Cell Physiol, 10.1152/ajpcell.00239.2001
Submitted on May 29, 2001
Accepted on November 19, 2001

Cellular Distribution of Parchorin, a Chloride Intracellular Channel-Related Protein, in Various Tissues

Yumiko Mizukawa1, Tomohiro Nishizawa1, Taku Nagao1, Ken Kitamura1, and Tetsuro Urushidani1*

1 Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan

* To whom correspondence should be addressed. E-mail: urushi{at}mol.f.u-tokyo.ac.jp.

The cellular distribution of parchorin, a new chloride intracellular channel family member, was investigated in rabbit tissues by immunohistochemistry using an antibody recognizing the sequence containing parchorin-specific repeat. Parchorin preferentially resides in the epithelium of ducts of lacrymal, parotid, submandibular, and mammary glands, and that of pancreas, prostate, and testis. In the trachea and lung, it existed in the airway epithelia and type II alveolar cells. In the kidney, parchorin distributed mainly from the thick ascending limb to distal convoluted tubule. In the eye, both pigment and nonpigment epithelia of ciliary body were positive, whereas only the pigment epithelia was positive in the retina. Parchorin was also present in cochlea and semicircular canal. The amount of parchorin in the gastric mucosa, but not in the submandibular glands, increased after weaning, and that in the mammary gland of pregnant rabbit increased after delivery. The cellular distribution and changes in expression indicate that parchorin plays an important role, possibly in chloride transport, of the cells that create an ion gradient for water movement.




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