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Articles in PresS, published online ahead of print June 26, 2002
Am J Physiol Cell Physiol, 10.1152/ajpcell.00173.2002
Submitted on April 16, 2002
Accepted on June 15, 2002
1 Physiology and Biophysics, University of California, Irvine, CA, USA
2 Orthopaedics, University of California, Irvine, CA, USA; Physiology and Biophysics, University of California, Irvine, CA, USA
* To whom correspondence should be addressed. E-mail: gradams{at}uci.edu.
Irradiation of rat skeletal muscles prior to increased loading has been shown to prevent compensatory hypertrophy for periods of up to 4 weeks, possibly by preventing satellite cells from proliferating and providing new myonuclei. Recent work has suggested that stem cell populations exist which might allow irradiated muscles to eventually hypertrophy over time. Here we report that 3 months of functional overload in irradiated rat muscles (OL&Ir) essentially prevented hypertrophy. The time course and magnitude of changes in cellular and molecular markers of anabolic and myogenic responses were similar in the OL&Ir and the contralateral non-irradiated, overloaded muscles (OL) for the first 3-7 days. These markers then returned to control levels in OL&Ir muscles while remaining elevated in OL. The number of myonuclei and amount of DNA was increased markedly in OL but not OL&Ir muscles. Thus it appears that stem cells were not added to the irradiated muscles in this time period. These data are consistent with the theory that the addition of new myonuclei may be required for compensatory hypertrophy in the rat.
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