| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Orthopaedics and Bioengineering, University of California, La Jolla, CA, USA
2 Biochemistry, University of Wisconsin, Madison, WI, USA
* To whom correspondence should be addressed. E-mail: rlieber{at}ucsd.edu.
Muscle LIM protein (MLP) has been suggested to be an important mediator of mechanical stress in cardiac tissue, but the role that it plays in skeletal muscle remains unclear. Previous studies showed that it was dramatically upregulated in fast-to-slow fiber type transformation and also after eccentric contraction-induced muscle injury (EC). The functional consequences of this upregulation, if any, are unclear. Here we examine the skeletal muscle phenotype of MLP knockout (MLPKO) mice, in terms of their response to ECs. The data suggest that, while the MLPKO mice recover completely after EC-induced injury, torque production lags behind heterozygous littermates in the early stages of the recovery process. This lag is accompanied by decreased expression of the muscle regulatory factor MyoD, suggesting that MLP may influence gene expression. In addition, there is evidence of type 1 fiber atrophy and a shorter resting sarcomere length in the MLPKO mice, but no significant differences in fiber type distribution. In summary, MLP appears to play a subtle role in the maintenance of normal muscle characteristics and in the early events of the recovery process of skeletal muscle to injury, serving both structural and gene regulatory roles.
This article has been cited by other articles:
|
|
 |
|
  M. Marotta, C. Ruiz-Roig, Y. Sarria, J. L. Peiro, F. Nunez, J. Ceron, F. Munell, and M. Roig-Quilis Muscle genome-wide expression profiling during disease evolution in mdx mice Physiol Genomics, April 10, 2009; 37(2): 119 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Velders, K. Legerlotz, S. J. Falconer, N. S. Stott, C. D. McMahon, and H. K. Smith Effect of botulinum toxin A-induced paralysis and exercise training on mechanosensing and signalling gene expression in juvenile rat gastrocnemius muscle Exp Physiol, December 1, 2008; 93(12): 1273 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Geier, K. Gehmlich, E. Ehler, S. Hassfeld, A. Perrot, K. Hayess, N. Cardim, K. Wenzel, B. Erdmann, F. Krackhardt, et al. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy Hum. Mol. Genet., September 15, 2008; 17(18): 2753 - 2765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. D. Kollias and J. C. McDermott Transforming growth factor-{beta} and myostatin signaling in skeletal muscle J Appl Physiol, March 1, 2008; 104(3): 579 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Clark, J. M. Bland, and M. C. Beckerle The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity J. Cell Sci., June 15, 2007; 120(12): 2066 - 2077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Y. Boateng, R. J. Belin, D. L. Geenen, K. B. Margulies, J. L. Martin, M. Hoshijima, P. P. de Tombe, and B. Russell Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H259 - H269. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
