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Articles in PresS, published online ahead of print September 4, 2002
Am J Physiol Cell Physiol, 10.1152/ajpcell.00111.2002
Submitted on March 12, 2002
Accepted on August 26, 2002
1 Institut Armand Frappier, INRS, Pointe Claire, Quebec, Canada
* To whom correspondence should be addressed. E-mail: daniel.cyr{at}inrs-sante.uquebec.ca.
In the epididymis, Cx43 forms gap junctions between principal and basal cells but not between adjacent principal cells. Cx30.3, 31.1, and 32 were identified in adult rat epididymis by RT-PCR while Cx26 was present in young rats. Postnatal development studies indicate that Cx26 mRNA was detectable only in the caput-corpus region of the epididymis and levels increased by 5-fold during the first 4 weeks postnatally, when epithelial cells differentiate, and decrease to non-detectable levels thereafter. Cx31.1 and Cx32 mRNA levels were low throughout the epididymis in young rats and begin to increase in the second and third week postnatally, when Cx26 levels are decreasing. Both Cx26 and Cx32 were localized to the lateral plasma membranes between adjacent epithelial cells of the epididymis. Colocalization studies indicate that Cx26 and Cx32 exist either independent of one another or they can colocalize along the lateral plasma membrane of epithelial cells in young rats or between principal cells in the adult rat epididymis. The presence of multiple Cxs and their differential regulation suggest that these play different roles in epididymal development.
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