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Am J Physiol Cell Physiol (September 11, 2002). doi:10.1152/ajpcell.00084.2002
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Articles in PresS, published online ahead of print September 11, 2002
Am J Physiol Cell Physiol, 10.1152/ajpcell.00084.2002
Submitted on February 25, 2002
Accepted on September 4, 2002

Circadian rhythms in surface molecules of rat blood lymphocytes

Carme Pelegri1*, Jordi Vilaplana2, Cristina Castellote1, Manel Rabanal1, Angels Franch1, and Margarida Castell1

1 Departament de Fisiologia - Divisio IV, Universitat de Barcelona, Grup d'Autoimmunitat i Tolerancia, Barcelona, Barcelona, Spain
2 Departament de Fisiologia - Divisio IV, Universitat de Barcelona, Grup de Cronobiologia, Barcelona, Barcelona, Spain

* To whom correspondence should be addressed. E-mail: cpelegri{at}farmacia.far.ub.es.

The present article examines whether the expression of certain surface molecules that trigger immune responses shows a circadian rhythm. We also analyzed the rhythms in the number and percentage of lymphocyte subpopulations, in the leukocyte differential counts, and in the total red and white blood cell counts. Blood samples obtained from rats at 2h intervals for 24 h were stained with several mouse monoclonal antibodies directed against lymphocyte surface molecules and processed by flow cytometry. The number of B, total T, T{gamma}{delta}, Th and Ts/c cells followed a 24-h rhythm with a peak in the first half of the resting period. The expression of CD45, CD5, CD3 and CD4 followed a circadian rhythm. Their acrophases suggested temporal association between CD45 and CD5 at the end of the active phase, and between CD4 and CD3 at the beginning of this phase. This temporal organization could have an important role for immune cell function.




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