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Am J Physiol Cell Physiol (May 22, 2002). doi:10.1152/ajpcell.00081.2002
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Articles in PresS, published online ahead of print May 22, 2002
Am J Physiol Cell Physiol, 10.1152/ajpcell.00081.2002
Submitted on February 19, 2002
Accepted on May 14, 2002

Neurotrophic factors enhance the survival of muscle fibers in extensor digitorum longus, but not soleus, after neonatal nerve injury

Kambiz Mousavi1*, Wilson Miranda2, and David J. Parry1

1 Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada; Centre for Neuromuscular Disease, Ottawa, Ontario, Canada
2 Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada

* To whom correspondence should be addressed. E-mail: kmous001{at}uottawa.ca.

Neonatal sciatic nerve crush results in a sustained reduction of the mass of both EDL and SOL muscles in the rat. Type IIB fibers are selectively lost from EDL. We have investigated the effects of ciliary neurotrophic factor (CNTF) combined with neurotrophin-3 (NT-3) or neurtrophin-4 (NT-4) on muscle mass, as well as the number, cross-sectional area and distribution of muscle fiber types and the number of motor neurons innervating EDL and SOL three months after transient axotomy 5 days after birth. Both neurotrophin (NT) treatments prevented the axotomy-induced loss of muscle mass in both EDL and SOL and of total number of muscle fibers in EDL but not in SOL. Although IIB fiber loss was not prevented, both NT treatments resulted in altered fiber type distribution. Both NT combinations also reduced the loss of EDL motor neurons. These data suggest that a differential distribution of NT receptors on either motor neurons or muscle fibers may lead to different levels of susceptibility to neonatal axotomy.




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