Am J Physiol Cell Physiol AJP: Lung Cellular and Molecular Physiology
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Am J Physiol Cell Physiol (April 3, 2002). doi:10.1152/ajpcell.00025.2002
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Articles in PresS, published online ahead of print April 3, 2002
Am J Physiol Cell Physiol, 10.1152/ajpcell.00025.2002
Submitted on January 18, 2002
Accepted on March 31, 2002

No decrease in myonuclear number after long-term denervation in mature mice

Ken-Ichi Wada, Hideyuki Takahashi, Shigeru Katsuta, and Hideaki Soya*

* To whom correspondence should be addressed. E-mail: soya{at}taiiku.tsukuba.ac.jp.

Age-related but not artificially induced muscle fiber atrophy has been shown to occur without any decrease in myonuclear number, although these results remain controversial. The present study was carried out to clarify whether age difference affects the degree of decrease in myonuclear number occurring with denervation-induced fiber atrophy. After denervation of 3-week (young) and 4-month-old (mature) mice, single-myofibers were isolated from the plantaris muscles by alkali maceration, and their fiber cross-sectional area (CSA), myonuclear number and cytoplasm-to-myonucleus (C/N) ratios were analyzed. Fiber CSA in both young and mature mice decreased with denervation. Myonuclear number decreased in young mice 5 and 10 days after denervation but was unchanged in mature mice 10 and 120 days after denervation. C/N ratio decreased in mature mice but was unchanged in denervated young mice. These results suggest that age differences affect the degree of decrease of myonuclear number with denervation and that fiber cytoplasmic atrophy may occur without decrease in myonuclear number.




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