Volume 283, December 2002 Volume 52, December 2002

Pages C1567-C1591: Kukkonen JP, Holmqvist T, Ammoun S, and Åkerman KEO. "Functions of the orexinergic/hypocretinergic system." On page C1568, the authors incorrectly stated in the first paragraph that "there was an error in the peptide sequences deduced by de Lecea and coworkers (37)." In fact, de Lecea et al. isolated the hypothalamic mRNA for the preproorexin and, based on that, deduced putative orexin A and orexin B sequences. These peptide sequences include a COOH-terminal glycine, which the authors suggested to be a substrate for COOH-terminal amidation. This was shown to be the case by Sakurai et al. (154). The NH₂ terminus of the orexin A peptide in (37) is too long, but those authors clearly state that the "N-terminal extent of Hcrt1 is not established." Thus, the sequences described in this excellent study (37) are correct but somewhat incomplete; the study of Sakurai et al. (154) went a bit further by verifying the COOH-terminal amidation, defining the full extent of the NH₂ terminus of orexin A, and identifying the disulfide bridges. This incorrect citation does not affect the actual review. (See http://ajpcell.physiology.org/cgi/content/full/283/6/C1568)