Volume 278, May 2000

Volume 47, May 2000

Pages C989-C997: Neal X. Chen, Kimberly D. Ryder, Fredrick M. Pavalko, Charles H. Turner, David B. Burr, Jinya Qiu, and Randall L. Duncan. "Ca²⁺ regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts." On page C993, Fig. 5 should appear as shown below (two images inadvertently included from Figs. 1B and 3 have been replaced with the correct images).

View larger version (108K): [in this window] [in a new window]   Fig.5. Cellular responses to shear are dependent on phospholipase C (PLC)-activated, IP3-mediated intracellular Ca2+ release. PLC inhibitors neomycin (10 mM) or U-73122 (10 µM) were added to MC3T3-E1 cells 30 min before application of 12 dyn/cm2 shear for 1 h. A: illustrates typical response of stress fiber formation and c-fos expression in untreated cells to shear. PLC inhibition with neomycin (B) or U-73122 (C) completely inhibits these responses. Response of MC3T3-E1 cells pretreated with inactive isoform of U-73122, U-73343 (D; 10 µM), was not significantly different from control cells. COX-2 production was affected in a similar manner. Magnification, ×60.