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Fig. 2.   Effect of colchicine (disrupter of actin and microtubules) on voltage-dependent Ca²⁺ current [I_Ba(L)]. Current-voltage (I-V) relationships were obtained for control (, n = 21) and after exposure to colchicine at 1 µM (, n = 14), 10 µM (, n = 14), and 100 µM (, n = 12). Data are expressed as means ± SE. As can be seen, the voltage for maximum current was +10 mV. Inset: current traces for control and after application of colchicine (100 µM). Cell capacitances were 59 pA (control cell) and 60 pA (colchicine-treated cell). E_m, membrane potential.

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