HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Kopic, S. Articles by Geibel, J. P PubMed PubMed Citation Articles by Kopic, S. Articles by Geibel, J. P

Review Article

Revisiting the parietal cell

¹Yale University

Submitted 27 October 2009 ; accepted in final form 27 October 2009

The parietal cell is responsible for secreting concentrated hydrochloric acid into the gastric lumen. To fulfill this task it is equipped with a broad variety of functionally coupled apical and basolateral ion transport proteins. The concerted scientific effort over the last years by a variety of researchers has provided us with the molecular identity of many of these transport mechanisms, thereby contributing to the clarification of persistent controversies in the field. This article will briefly review the current model of parietal cell physiology and ion transport in particular and will update the existing models of apical and basolateral transport in the parietal cell.

gastric acid secretion; stomach; pH; H,K-ATPase