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METHODS IN CELL PHYSIOLOGY

Software for simulating calcium-triggered exocytotic processes

¹Departamento de Matemáticas, Estadística y Computación, Universidad de Cantabria, Santander; and ²CABINER, Américo Vespucio S/N, Seville, Spain

Submitted 20 February 2006 ; accepted in final form 26 August 2006

We describe a software package for the simulation of exocytotic events from readily releasable pools of secretory vesicles in neuroendocrine cells and presynaptic terminals. The visual package Ca3D_Exolab simulates the entry of Ca²⁺ through the calcium channels, the kinetic reactions of calcium with buffers, the diffusion of calcium and mobile buffers, and the kinetic reactions of calcium with the secretory vesicles. The location of both channels and secretory vesicles can be set by using a graphical interface. Calcium and buffer concentrations at different depths from the cellular membrane and capacitance time courses are obtained as outputs. The software package also provides a descriptive statistical data analysis of the different output data.

modeling of exocytosis; Monte Carlo methods