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Am J Physiol Cell Physiol 289: C1312-C1320, 2005. First published August 10, 2005; doi:10.1152/ajpcell.00117.2005
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MUSCLE CELL BIOLOGY AND CELL MOTILITY

Muscle LIM protein plays both structural and functional roles in skeletal muscle

Ilona A. Barash,1 Liby Mathew,1 Michele Lahey,1 Marion L. Greaser,2 and Richard L. Lieber1

1Departments of Orthopaedics and Bioengineering and the Biomedical Sciences Graduate Group, University of California and Veterans Administration Medical Centers, San Diego, California; and 2Muscle Biology Laboratory, University of Wisconsin, Madison, Wisconsin

Submitted 14 March 2005 ; accepted in final form 24 June 2005

Muscle LIM protein (MLP) has been suggested to be an important mediator of mechanical stress in cardiac tissue, but the role that it plays in skeletal muscle remains unclear. Previous studies have shown that it is dramatically upregulated in fast-to-slow fiber-type transformation and also after eccentric contraction (EC)-induced muscle injury. The functional consequences of this upregulation, if any, are unclear. In the present study, we have examined the skeletal muscle phenotype of MLP-knockout (MLPKO) mice in terms of their response to EC-induced muscle injuries. The data suggest that while the MLPKO mice recover completely after EC-induced injury, their torque production lags behind that of heterozygous littermates in the early stages of the recovery process. This lag is accompanied by decreased expression of the muscle regulatory factor MyoD, suggesting that MLP may influence gene expression. In addition, there is evidence of type I fiber atrophy and a shorter resting sarcomere length in the MLPKO mice, but no significant differences in fiber type distribution. In summary, MLP appears to play a subtle role in the maintenance of normal muscle characteristics and in the early events of the recovery process of skeletal muscle to injury, serving both structural and gene-regulatory roles.

eccentric contractions; passive tension


Address for reprint requests and other correspondence: R. L. Lieber, Dept. of Orthopaedics, Veterans Affairs Medical Center and Univ. of California, San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161 (e-mail: rlieber{at}ucsd.edu)




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