HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (20) Citing Articles via Google Scholar Google Scholar Articles by Strange, K. Search for Related Content PubMed PubMed Citation Articles by Strange, K.

PERSPECTIVES IN CELL PHYSIOLOGY

The end of "naïve reductionism": rise of systems biology or renaissance of physiology?

Departments of Anesthesiology, Molecular Physiology and Biophysics, and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee

Submitted 7 December 2004 ; accepted in final form 13 December 2004

ABSTRACT

Systems biology is an emerging discipline focused on tackling the enormous intellectual and technical challenges associated with translating genome sequence into a comprehensive understanding of how organisms are built and run. Physiology and systems biology share the goal of understanding the integrated function of complex, multicomponent biological systems ranging from interacting proteins that carry out specific tasks to whole organisms. Despite this common ground, physiology as an academic discipline runs the real risk of fading into the background and being superseded organizationally and administratively by systems biology. My goal in this article is to discuss briefly the cornerstones of modern systems biology, specifically functional genomics, nonmammalian model organisms and computational biology, and to emphasize the need to embrace them as essential components of 21st-century physiology departments and research and teaching programs.

functional genomics; model organisms; genetics

This article has been cited by other articles:

				L. A. Cogburn, T. E. Porter, M. J. Duclos, J. Simon, S. C. Burgess, J. J. Zhu, H. H. Cheng, J. B. Dodgson, and J. Burnside Functional Genomics of the Chicken A Model Organism Poult. Sci., October 1, 2007; 86(10): 2059 - 2094. [Abstract] [Full Text] [PDF]

				S. M. Studer and N. Kaminski Towards Systems Biology of Human Pulmonary Fibrosis Proceedings of the ATS, January 1, 2007; 4(1): 85 - 91. [Abstract] [Full Text] [PDF]

				D. A. Beard and M. Vendelin Systems biology of the mitochondrion. Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1101 - C1103. [Full Text] [PDF]

				A. Chambellan, P. J. Cruickshank, P. McKenzie, S. B. Cannady, K. Szabo, S. A. A. Comhair, and S. C. Erzurum Gene Expression Profile of Human Airway Epithelium Induced by Hyperoxia In Vivo Am. J. Respir. Cell Mol. Biol., October 1, 2006; 35(4): 424 - 435. [Abstract] [Full Text] [PDF]

				D. B. Bylund, L. L. Brunton, P. J. R. Cobbett, A. M. Persky, and P. C. Preusch NIGMS-Sponsored Integrative and Organ Systems Pharmacology: Synopsis of the 2005 Experience/Anticipation of the 2006 Short Courses Mol. Interv., December 1, 2005; 5(6): 330 - 333. [Full Text] [PDF]