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Am J Physiol Cell Physiol 286: C195-C205, 2004; doi:10.1152/ajpcell.00365.2003
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INVITED REVIEW

TRPV4 calcium entry channel: a paradigm for gating diversity

Bernd Nilius, Joris Vriens, Jean Prenen, Guy Droogmans, and Thomas Voets

Department of Physiology, Campus Gasthuisberg, Katholieke Universiteit Leuven, 3000 Leuven, Belgium

The vanilloid receptor-1 (VR1, now TRPV1) was the founding member of a subgroup of cation channels within the TRP family. The TRPV subgroup contains six mammalian members, which all function as Ca2+ entry channels gated by a variety of physical and chemical stimuli. TRPV4, which displays 45% sequence identity with TRPV1, is characterized by a surprising gating promiscuity: it is activated by hypotonic cell swelling, heat, synthetic 4{alpha}-phorbols, and several endogenous substances including arachidonic acid (AA), the endocannabinoids anandamide and 2-AG, and cytochrome P-450 metabolites of AA, such as epoxyeicosatrienoic acids. This review summarizes data on TRPV4 as a paradigm of gating diversity in this subfamily of Ca2+ entry channels.

transient receptor potential; calcium channels; vanilloid receptor


Address for reprint requests and other correspondence: B. Nilius, Laboratorium voor Fysiologie, KU Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium (E-mail: Bernd.Nilius{at}med.kuleuven.ac.be).




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