Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 284: C826-C838, 2003. First published November 27, 2002; doi:10.1152/ajpcell.00465.2002
0363-6143/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/4/C826    most recent
00465.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, S. J.
Right arrow Articles by McHowat, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, S. J.
Right arrow Articles by McHowat, J.
Vol. 284, Issue 4, C826-C838, April 2003

Alterations in Ca2+ cycling by lysoplasmenylcholine in adult rabbit ventricular myocytes

Shi J. Liu1, Richard H. Kennedy1, Michael H. Creer2, and Jane McHowat2

1 Departments of Pharmaceutical Sciences and Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205; and 2 Department of Pathology, St. Louis University Medical School, St. Louis, Missouri 63104

We previously reported that lysoplasmenylcholine (LPlasC) altered the action potential (AP) and induced afterdepolarizations in rabbit ventricular myocytes. In this study, we investigated how LPlasC alters excitation-contraction coupling using edge-motion detection, fura-PE3 fluorescent indicator, and perforated and whole cell patch-clamp techniques. LPlasC increased contraction, myofilament Ca2+ sensitivity, systolic and diastolic free Ca2+ levels, and the magnitude of Ca2+ transients concomitant with increases in the maximum rates of shortening and relaxation of contraction and the rising and declining phases of Ca2+ transients. In some cells, LPlasC induced arrhythmias in a pattern consistent with early and delayed aftercontractions. LPlasC also augmented the caffeine-induced Ca2+ transient with a reduction in the decay rate. Furthermore, LPlasC enhanced L-type Ca2+ channel current (ICa,L) and outward currents. LPlasC-induced alterations in contraction and ICa,L were paralleled by its effect on the AP. Thus these results suggest that LPlasC elicits distinct, potent positive inotropic, lusitropic, and arrhythmogenic effects, resulting from increases in Ca2+ influx, Ca2+ sensitivity, sarcoplasmic reticular (SR) Ca2+ release and uptake, SR Ca2+ content, and probably reduction in sarcolemmal Na+/Ca2+ exchange.

calcium; lipid metabolites; excitation-contraction coupling; heart


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
M. C. White, P. Rastogi, and J. McHowat
Lysoplasmenylcholine increases neutrophil adherence to human coronary artery endothelial cells
Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1467 - C1471.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. J. Liu
Inhibition of L-type Ca2+ channel current and negative inotropy induced by arachidonic acid in adult rat ventricular myocytes
Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1594 - C1604.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. C. Meyer and J. McHowat
Calcium-independent phospholipase A2-catalyzed plasmalogen hydrolysis in hypoxic human coronary artery endothelial cells
Am J Physiol Cell Physiol, January 1, 2007; 292(1): C251 - C258.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. S. Beckett, K. Pennington, and J. McHowat
Activation of MAPKs in thrombin-stimulated ventricular myocytes is dependent on Ca2+-independent PLA2
Am J Physiol Cell Physiol, May 1, 2006; 290(5): C1350 - C1354.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
M. Dworschak, D. Breukelmann, and J. D. Hannon
The Impact of Isoflurane During Simulated Ischemia/Reoxygenation on Intracellular Calcium, Contractile Function, and Arrhythmia in Ventricular Myocytes
Anesth. Analg., November 1, 2004; 99(5): 1302 - 1307.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. J. Liu and R. H. Kennedy
Positive inotropic effect of ceramide in adult ventricular myocytes: mechanisms dissociated from its reduction in Ca2+ influx
Am J Physiol Heart Circ Physiol, July 11, 2003; 285(2): H735 - H744.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Yu, R. H. Kennedy, and S. J. Liu
JAK2/STAT3, Not ERK1/2, Mediates Interleukin-6-induced Activation of Inducible Nitric-oxide Synthase and Decrease in Contractility of Adult Ventricular Myocytes
J. Biol. Chem., April 25, 2003; 278(18): 16304 - 16309.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online