| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557; and 2 Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 467-8603 Nagoya, Japan
A-type currents are voltage-gated, calcium-independent potassium (Kv) currents that undergo rapid activation and inactivation. Commonly associated with neuronal and cardiac cell-types, A-type currents have also been identified and characterized in vascular, genitourinary, and gastrointestinal smooth muscle cells. This review examines the molecular identity, biophysical properties, pharmacology, regulation, and physiological function of smooth muscle A-type currents. In general, this review is intended to facilitate the comparison of A-type currents present in different smooth muscles by providing a comprehensive report of the literature to date. This approach should also aid in the identification of areas of research requiring further attention.
smooth muscle; Kv4 channels; potassium channel-interacting proteins
This article has been cited by other articles:
|
|
 |
|
  C. Xie, V. E. Bondarenko, M. J. Morales, and H. C. Strauss Closed-state inactivation in Kv4.3 isoforms is differentially modulated by protein kinase C Am J Physiol Cell Physiol, November 1, 2009; 297(5): C1236 - C1248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Dua, N. Dua, and C. L. Murrant Skeletal muscle contraction-induced vasodilator complement production is dependent on stimulus and contraction frequency Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H433 - H442. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Armstrong, A. K. Dua, and C. L. Murrant Potassium initiates vasodilatation induced by a single skeletal muscle contraction in hamster cremaster muscle J. Physiol., June 1, 2007; 581(2): 841 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Qu, V. E. Bondarenko, C. Xie, S. Wang, M. S. Awayda, H. C. Strauss, and M. J. Morales W-7 modulates Kv4.3: pore block and Ca2+-calmodulin inhibition Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2364 - H2377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Amberg and L. F. Santana Kv2 channels oppose myogenic constriction of rat cerebral arteries Am J Physiol Cell Physiol, August 1, 2006; 291(2): C348 - C356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. H. Beckett, C. McCloskey, N. O'Kane, K. M. Sanders, and S. Don Koh Effects of female steroid hormones on A-type K+ currents in murine colon J. Physiol., June 1, 2006; 573(2): 453 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ono, T. Toyono, E. Honda, and K. Inenaga Transient outward K+ currents in rat dissociated subfornical organ neurones and angiotensin II effects J. Physiol., November 1, 2005; 568(3): 979 - 991. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Werner, P. Zvara, A. L. Meredith, R. W. Aldrich, and M. T. Nelson Erectile dysfunction in mice lacking the large-conductance calcium-activated potassium (BK) channel J. Physiol., September 1, 2005; 567(2): 545 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Wang, M. Shahidullah, C. A. Rocha, C. Strang, P. J. Pfaffinger, and M. Covarrubias Functionally Active T1-T1 Interfaces Revealed by the Accessibility of Intracellular Thiolate Groups in Kv4 Channels J. Gen. Physiol., June 27, 2005; 126(1): 55 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yun Cho, E. A. Beckett, S. A. Baker, I. Han, K. J. Park, K. Monaghan, S. M. Ward, K. M. Sanders, and S. D. Koh A pH-sensitive potassium conductance (TASK) and its function in the murine gastrointestinal tract J. Physiol., May 15, 2005; 565(1): 243 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. I. Akbarali Signal-Transduction Pathways that Regulate Smooth Muscle Function II. Receptor-ion channel coupling mechanisms in gastrointestinal smooth muscle Am J Physiol Gastrointest Liver Physiol, April 1, 2005; 288(4): G598 - G602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takeda, S. M. Ward, K. M. Sanders, and S. D. Koh Effects of the gap junction blocker glycyrrhetinic acid on gastrointestinal smooth muscle cells Am J Physiol Gastrointest Liver Physiol, April 1, 2005; 288(4): G832 - G841. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Suzuki and K. Takimoto Differential expression of Kv4 pore-forming and KChIP auxiliary subunits in rat uterus during pregnancy Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E335 - E341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Birnbaum, A. W. Varga, L.-L. Yuan, A. E. Anderson, J. D. Sweatt, and L. A. Schrader Structure and Function of Kv4-Family Transient Potassium Channels Physiol Rev, July 1, 2004; 84(3): 803 - 833. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
