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Am J Physiol Cell Physiol 284: C67-C76, 2003. First published September 11, 2002; doi:10.1152/ajpcell.00084.2002
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Vol. 284, Issue 1, C67-C76, January 2003

Circadian rhythms in surface molecules of rat blood lymphocytes

Carme Pelegrí1, Jordi Vilaplana2, Cristina Castellote1, Manel Rabanal1, Àngels Franch1, and Margarida Castell1

1 Grup d'Autoimmunitat i Tolerància, 2 Grup de Cronobiologia, Departament de Fisiologia- Divisió IV, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain

The present article examines whether the expression of certain surface molecules that trigger immune responses shows a circadian rhythm. We also analyzed the rhythms in the number and percentage of lymphocyte subpopulations, in the leukocyte differential counts, and in the total red and white blood cell counts. Blood samples obtained from rats at 2-h intervals for 24 h were stained with several mouse monoclonal antibodies directed against lymphocyte surface molecules and processed by flow cytometry. The number of B, total T, Tgamma delta , Th, and Ts/c cells followed a 24-h rhythm with a peak in the first half of the resting period. The expression of CD45, CD5, CD3, and CD4 followed a circadian rhythm. Their acrophases suggested temporal association between CD45 and CD5 at the end of the active phase and between CD4 and CD3 at the beginning of this phase. This temporal organization could have an important role for immune cell function.

leukocytes; CD3; CD4, CD5; CD45


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