Am J Physiol Cell Physiol AJP: Regulatory, Integrative and Comparative Physiology
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Am J Physiol Cell Physiol 284: C103-C110, 2003. First published September 18, 2002; doi:10.1152/ajpcell.00165.2002
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Vol. 284, Issue 1, C103-C110, January 2003

Granulocyte colony-stimulating factor promotes adhesion of neutrophils

Arup Chakraborty1,2, Eric R. Hentzen2,3, Scott M. Seo2,3, and C. Wayne Smith2

1 Section of Infectious Diseases, Department of Medicine, and 2 Section of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine; and 3 Department of Biomedical Engineering, Rice University, Houston, Texas 77030

Granulocyte colony stimulating factor (G-CSF) is well known for its ability to drive the maturation and mobilization of neutrophils. G-CSF also appears to have the potential to activate functions of mature neutrophils, influencing recruitment at sites of inflammation and tissue injury. We investigated the ability of G-CSF to stimulate adhesion of isolated blood neutrophils. G-CSF induced significant adherence to intercellular adhesion molecule (ICAM)-1 that was both macrophage antigen-1 (Mac-1) and leukocyte function-associated antigen-1 dependent. The kinetics of G-CSF-stimulated adhesion to ICAM-1 peaked at 11 min without detectable surface upregulation of Mac-1. This was in marked contrast to chemokines, in which peak activation of adhesion is seen within 1 min of stimulation. In contrast to chemokine-induced adhesion, G-CSF stimulation was not inhibited by pertussis toxin. G-CSF also augmented the attachment of neutrophils to activated human umbilical vein endothelial cells (HUVEC) through specific effects on neutrophils, because HUVEC appear to lack functional G-CSF receptors.

granulocyte colony-stimulating factor; intracellular adhesion molecule-1; leukocyte function-associated antigen-1; macrophage antigen-1; adhesion; polymorphonuclear neutrophils


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