Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 283: C1228-C1241, 2002. First published June 26, 2002; doi:10.1152/ajpcell.00206.2002
0363-6143/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/4/C1228    most recent
00206.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (21)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chargé, S. B. P.
Right arrow Articles by Hughes, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chargé, S. B. P.
Right arrow Articles by Hughes, S. M.
Vol. 283, Issue 4, C1228-C1241, October 2002

Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy

Sophie B. P. Chargé, Andrew S. Brack, and Simon M. Hughes

Medical Research Council (MRC) Muscle and Cell Motility Unit and MRC Centre for Developmental Neurobiology, Guy's Campus, King's College London, London SE1 1UL, United Kingdom

To investigate the cause of skeletal muscle weakening during aging we examined the sequence of cellular changes in murine muscles. Satellite cells isolated from single muscle fibers terminally differentiate progressively less well with increasing age of donor. This change is detected before decline in satellite cell numbers and all histological changes examined here. In MSVski transgenic mice, which show type IIb fiber hypertrophy, initial muscle weakness is followed by muscle degeneration in the first year of life. This degeneration is accompanied by a spectrum of changes typical of normal muscle aging and a more marked decline in satellite cell differentiation efficiency. On a myoD-null genetic background, in which satellite cell differentiation is defective, the MSVski muscle phenotype is aggravated. This suggests that, on a wild-type genetic background, satellite cells are capable of repairing MSVski fibers and preserving muscle integrity in early life. We propose that decline in myogenic cell differentiation efficiency is an early event in aging-related loss of muscle function, both in normal aging and in some late-onset muscle degenerative conditions.

muscle regeneration; MyoD; myonuclear domain size


This article has been cited by other articles:


Home page
 PhysiologyHome page
M. Sandri
Signaling in Muscle Atrophy and Hypertrophy
Physiology, June 1, 2008; 23(3): 160 - 170.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. J. Lees, C. R. Rathbone, and F. W. Booth
Age-associated decrease in muscle precursor cell differentiation
Am J Physiol Cell Physiol, February 1, 2006; 290(2): C609 - C615.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
S. Kuang, S. B. Charge, P. Seale, M. Huh, and M. A. Rudnicki
Distinct roles for Pax7 and Pax3 in adult regenerative myogenesis
J. Cell Biol., January 3, 2006; 172(1): 103 - 113.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. S. Brack, H. Bildsoe, and S. M. Hughes
Evidence that satellite cell decrement contributes to preferential decline in nuclear number from large fibres during murine age-related muscle atrophy
J. Cell Sci., October 15, 2005; 118(20): 4813 - 4821.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad, F. Zaldivar, D. M. Cooper, and G. R. Adams
IL-6-induced skeletal muscle atrophy
J Appl Physiol, March 1, 2005; 98(3): 911 - 917.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
S. B. P. CHARGE and M. A. RUDNICKI
Cellular and Molecular Regulation of Muscle Regeneration
Physiol Rev, January 1, 2004; 84(1): 209 - 238.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Haddad, R. R. Roy, H. Zhong, V. R. Edgerton, and K. M. Baldwin
Atrophy responses to muscle inactivity. I. Cellular markers of protein deficits
J Appl Physiol, August 1, 2003; 95(2): 781 - 790.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online