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Am J Physiol Cell Physiol 283: C42-C47, 2002; doi:10.1152/ajpcell.00416.2001
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Vol. 283, Issue 1, C42-C47, July 2002

Prolonged force increase following a high-frequency burst is not due to a sustained elevation of [Ca2+]i

F. Abbate1, J. D. Bruton2, A. De Haan1,3, and H. Westerblad2

1 Institute for Fundamental and Clinical Human Movement Sciences, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands; 2 Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden; and 3 Neuromuscular Biology Research Group, Manchester Metropolitan University, Alsager, ST 7 2 HL, United Kingdom

A brief high-frequency burst of action potentials results in a sustained force increase in skeletal muscle. The present study investigates whether this force potentiation is the result of a sustained increase of the free myoplasmic [Ca2+] ([Ca2+]i). Single fibers from mouse flexor brevis muscles were stimulated with three impulses at 150 Hz (triplet) at the start of a 350-ms tetanus or in the middle of a 700-ms tetanus; the stimulation frequency of the rest of the tetanus ranged from 20 to 60 Hz. After the triplet, force was significantly (P < 0.05) increased between 17 and 20% when the triplet was given at the start of the tetanus and between 5 and 18% when the triplet was given in the middle (n = 7). However, during this potentiation, [Ca2+]i was not consistently increased. Hence, the increased force following a high-frequency burst is likely due to changes in the myofibrillar properties.

force potentiation; excitation contraction coupling; mechanical output; skeletal muscle; Ca2+


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