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Am J Physiol Cell Physiol 282: C1191-C1198, 2002; doi:10.1152/ajpcell.00475.2001
0363-6143/02 $5.00
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Vol. 282, Issue 6, C1191-C1198, June 2002

INVITED REVIEW
Nicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?

Eduardo N. Chini1 and Frederico G. S. De Toledo2

1 Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota 55905; and 2 Department of Internal Medicine, University of Miami, Jackson Memorial Medical Center, Miami, Florida 33136

Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca2+ release known to date. The role of the NAADP system in physiological processes is being extensively investigated at the present time. Exciting new discoveries in the last 5 years suggest that the NAADP-regulated system may have a significant role in intracellular Ca2+ signaling. The NAADP receptor and its associated Ca2+ pool have been hypothesized to be important in several physiological processes including fertilization, T cell activation, and pancreatic secretion. However, whether NAADP is a new second messenger or a tool for the discovery of a new Ca2+ channel is still an unanswered question.

calcium; endoplasmic reticulum; fertilization; sea urchin eggs; cyclic adenosine 5'-diphosphate-ribose


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