| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506-5802; and 2 Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455
Stria vascularis of the cochlea generates the endocochlear potential and secretes K+. K+ is the main charge carrier and the endocochlear potential the main driving force for the sensory transduction that leads to hearing. Stria vascularis consists of two barriers, marginal cells that secrete potassium and basal cells that are coupled via gap junctions to intermediate cells. Mice lacking the KCNJ10 (Kir4.1) K+ channel in strial intermediate cells did not generate an endocochlear potential. Endolymph volume and K+ concentration ([K+]) were reduced. These studies establish that the KCNJ10 K+ channel provides the molecular mechanism for generation of the endocochlear potential in concert with other transport pathways that establish the [K+] difference across the channel. KCNJ10 is also a limiting pathway for K+ secretion.
stria vascularis; null mutation; mouse; transepithelial potential; potassium secretion
This article has been cited by other articles:
|
|
 |
|
  D. Bockenhauer, S. Feather, H. C. Stanescu, S. Bandulik, A. A. Zdebik, M. Reichold, J. Tobin, E. Lieberer, C. Sterner, G. Landoure, et al. Epilepsy, Ataxia, Sensorineural Deafness, Tubulopathy, and KCNJ10 Mutations N. Engl. J. Med., May 7, 2009; 360(19): 1960 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mustapha, Q. Fang, T.-W. Gong, D. F. Dolan, Y. Raphael, S. A. Camper, and R. K. Duncan Deafness and Permanently Reduced Potassium Channel Gene Expression and Function in Hypothyroid Pit1dw Mutants J. Neurosci., January 28, 2009; 29(4): 1212 - 1223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dutton, L. Abbas, J. Spencer, C. Brannon, C. Mowbray, M. Nikaido, R. N. Kelsh, and T. T. Whitfield A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle Dis. Model. Mech., January 1, 2009; 2(1-2): 68 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-O. Trowe, H. Maier, M. Schweizer, and A. Kispert Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes Development, May 1, 2008; 135(9): 1725 - 1734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Singh and P. Wangemann Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model Am J Physiol Renal Physiol, January 1, 2008; 294(1): F139 - F148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Djukic, K. B. Casper, B. D. Philpot, L.-S. Chin, and K. D. McCarthy Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation J. Neurosci., October 17, 2007; 27(42): 11354 - 11365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lang, V. Vallon, M. Knipper, and P. Wangemann Functional significance of channels and transporters expressed in the inner ear and kidney Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1187 - C1208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gao, S. F. Maison, X. Wu, K. Hirose, S. M. Jones, I. Bayazitov, Y. Tian, G. Mittleman, D. B. Matthews, S. S. Zakharenko, et al. Orphan Glutamate Receptor {delta}1 Subunit Required for High-Frequency Hearing Mol. Cell. Biol., June 15, 2007; 27(12): 4500 - 4512. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nakaya, D. G. Harbidge, P. Wangemann, B. D. Schultz, E. D. Green, S. M. Wall, and D. C. Marcus Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1314 - F1321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wangemann, K. Nakaya, T. Wu, R. J. Maganti, E. M. Itza, J. D. Sanneman, D. G. Harbidge, S. Billings, and D. C. Marcus Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1345 - F1353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shibata, H. Hibino, K. Doi, T. Suzuki, Y. Hisa, and Y. Kurachi Gastric type H+,K+-ATPase in the cochlear lateral wall is critically involved in formation of the endocochlear potential Am J Physiol Cell Physiol, November 1, 2006; 291(5): C1038 - C1048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hibino and Y. Kurachi Molecular and physiological bases of the k+ circulation in the Mammalian inner ear. Physiology, October 1, 2006; 21: 336 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Wangemann Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential J. Physiol., October 1, 2006; 576(1): 11 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Knipper, C. Claussen, L. Ruttiger, U. Zimmermann, R. Lullmann-Rauch, E.-L. Eskelinen, J. Schroder, M. Schwake, and P. Saftig Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis J. Physiol., October 1, 2006; 576(1): 73 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Neusch, N. Papadopoulos, M. Muller, I. Maletzki, S. M. Winter, J. Hirrlinger, M. Handschuh, M. Bahr, D. W. Richter, F. Kirchhoff, et al. Lack of the Kir4.1 Channel Subunit Abolishes K+ Buffering Properties of Astrocytes in the Ventral Respiratory Group: Impact on Extracellular K+ Regulation J Neurophysiol, March 1, 2006; 95(3): 1843 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Nie, M. A. Gratton, K. J. Mu, J. N. Dinglasan, W. Feng, and E. N. Yamoah Expression and Functional Phenotype of Mouse ERG K+ Channels in the Inner Ear: Potential Role in K+ Regulation in the Inner Ear J. Neurosci., September 21, 2005; 25(38): 8671 - 8679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gow, C. Davies, C. M. Southwood, G. Frolenkov, M. Chrustowski, L. Ng, D. Yamauchi, D. C. Marcus, and B. Kachar Deafness in Claudin 11-Null Mice Reveals the Critical Contribution of Basal Cell Tight Junctions to Stria Vascularis Function J. Neurosci., August 11, 2004; 24(32): 7051 - 7062. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A Moreno-Pelayo, S Modamio-Hoybjor, A Mencia, I del Castillo, S Chardenoux, M Fernandez-Burriel, M Lathrop, C Petit, and F Moreno DFNA49, a novel locus for autosomal dominant non-syndromic hearing loss, maps proximal to DFNA7/DFNM1 region on chromosome 1q21-q23 J. Med. Genet., November 1, 2003; 40(11): 832 - 836. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ben-Yosef, I. A. Belyantseva, T. L. Saunders, E. D. Hughes, K. Kawamoto, C. M. Van Itallie, L. A. Beyer, K. Halsey, D. J. Gardner, E. R. Wilcox, et al. Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration Hum. Mol. Genet., August 15, 2003; 12(16): 2049 - 2061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-C. Gamp, Y. Tanaka, R. Lullmann-Rauch, D. Wittke, R. D'Hooge, P. P. De Deyn, T. Moser, H. Maier, D. Hartmann, K. Reiss, et al. LIMP-2/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice Hum. Mol. Genet., March 15, 2003; 12(6): 631 - 646. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
