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Am J Physiol Cell Physiol 282: C347-C359, 2002. First published November 14, 2001; doi:10.1152/ajpcell.00283.2001
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Vol. 282, Issue 2, C347-C359, February 2002

TRPC6 is a candidate channel involved in receptor-stimulated cation currents in A7r5 smooth muscle cells

Silke Jung, Rainer Strotmann, Günter Schultz, and Tim D. Plant

Institut für Pharmakologie, Freie Universität Berlin, 14195 Berlin, Germany

To investigate the possible role of members of the mammalian transient receptor potential (TRP) channel family (TRPC1-7) in vasoconstrictor-induced Ca2+ entry in vascular smooth muscle cells, we studied [Arg8]-vasopressin (AVP)-activated channels in A7r5 aortic smooth muscle cells. AVP induced an increase in free cytosolic Ca2+ concentration ([Ca2+]i) consisting of Ca2+ release and Ca2+ influx. Whole cell recordings revealed the activation of a nonselective cation current with a doubly rectifying current-voltage relation strikingly similar to those described for some heterologously expressed TRPC isoforms. The current was also stimulated by direct activation of G proteins as well as by activation of the phospholipase Cgamma -coupled platelet-derived growth factor receptor. Currents were not activated by store depletion or increased [Ca2+]i. Application of 1-oleoyl-2-acetyl-sn-glycerol stimulated the current independently of protein kinase C, a characteristic property of the TRPC3/6/7 subfamily. Like TRPC6-mediated currents, cation currents in A7r5 cells were increased by flufenamate. Northern hybridization revealed mRNA coding for TRPC1 and TRPC6. We therefore suggest that TRPC6 is a molecular component of receptor-stimulated Ca2+-permeable cation channels in A7r5 smooth muscle cells.

transient receptor potential channel; calcium ion influx; receptor-operated channel


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