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Am J Physiol Cell Physiol 281: C1259-C1265, 2001;
0363-6143/01 $5.00
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Vol. 281, Issue 4, C1259-C1265, October 2001

Effect of glutamine supplementation on exercise-induced changes in lymphocyte function

Karen Krzywkowski1, Emil Wolsk Petersen1, Kenneth Ostrowski1, Jens Halkjær Kristensen2, Julio Boza3, and Bente Klarlund Pedersen1

1 Copenhagen Muscle Research Centre and Department of Infectious Diseases, and 2 Department of Orthopedic Medicine and Rehabilitation, Rigshospitalet, 2200 Copenhagen N, Denmark; and 3 Nestlé Research Center CH100, Lausanne, Switzerland

The purpose of this study was to investigate the possible role of glutamine in exercise-induced impairment of lymphocyte function. Ten male athletes participated in a randomized, placebo-controlled, double-blind crossover study. Each athlete performed bicycle exercise for 2 h at 75% of maximum O2 consumption on 2 separate days. Glutamine or placebo supplements were given orally during and up to 2 h postexercise. The trial induced postexercise neutrocytosis that lasted at least 2 h. The total lymphocyte count increased by the end of exercise due to increase of both CD3+TCRalpha beta + and CD3+TCRgamma delta + T cells as well as CD3-CD16+CD56+ natural killer (NK) cells. Concentrations of CD8+ and CD4+ T cells lacking CD28 and CD95 on their surface increased more than those of cells expressing these receptors. Within the CD4+ cells, only CD45RA- memory cells, but not CD45RA+ naive cells, increased in response to exercise. Most lymphocyte subpopulations decreased 2 h after exercise. Glutamine supplementation abolished the postexercise decline in plasma glutamine concentration but had no effect on lymphocyte trafficking, NK and lymphokine-activated killer cell activities, T cell proliferation, catecholamines, growth hormone, insulin, or glucose. Neutrocytosis was less pronounced in the glutamine-supplemented group, but it is unlikely that this finding is of any clinical significance. This study does not support the idea that glutamine plays a mechanistic role in exercise-induced immune changes.

training; physical activity; immunology; natural killer cells


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