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1 Department of Cellular and Molecular Physiology, School of Medicine, Yale University, New Haven, Connecticut 06520; 2 Department of Physiology, University of Tübingen, 72076 Tübingen, Germany; and 3 Division of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
Heterodimeric amino acid transporters are comprised of two
subunits, a polytopic membrane protein (light chain) and an associated type II membrane protein (heavy chain). The heavy chain rbAT (related to b0,+ amino acid transporter) associates with the light
chain b0,+AT (b0,+ amino acid transporter) to
form the amino acid transport system b0,+, whereas the
homologous heavy chain 4F2hc interacts with several light chains to
form system L (with LAT1 and LAT2), system y+L (with
y+LAT1 and y+LAT2), system x
heavy and light chains; disulfide bridge; cystinuria; lysinuric protein intolerance
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