Am J Physiol Cell Physiol AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 280: C1616-C1622, 2001;
0363-6143/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Duerr, J. S.
Right arrow Articles by Rand, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duerr, J. S.
Right arrow Articles by Rand, J. B.
Vol. 280, Issue 6, C1616-C1622, June 2001

SPECIAL COMMUNICATION
Identified neurons in C. elegans coexpress vesicular transporters for acetylcholine and monoamines

Janet S. Duerr, Jennifer Gaskin, and James B. Rand

Program in Molecular and Cell Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104

We have identified four neurons (VC4, VC5, HSNL, HSNR) in Caenorhabditis elegans adult hermaphrodites that express both the vesicular acetylcholine transporter and the vesicular monoamine transporter. All four of these cells are motor neurons that innervate the egg-laying muscles of the vulva. In addition, they all express choline acetyltransferase, the synthetic enzyme for acetylcholine. The distributions of the vesicular acetylcholine transporter and the vesicular monoamine transporter are not identical within the individual cells. In mutants deficient for either of these transporters, there is no apparent compensatory change in the expression of the remaining transporter. This is the first report of neurons that express two different vesicular neurotransmitter transporters in vivo.

vesicular acetylcholine transporter; vesicular monoamine transporter; Caenorhabditis elegans; cotransmission; nematode


This article has been cited by other articles:


Home page
 JCBHome page
S. L. Edwards, N. K. Charlie, J. E. Richmond, J. Hegermann, S. Eimer, and K. G. Miller
Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2
J. Cell Biol., September 21, 2009; 186(6): 881 - 895.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Y. Biala, J. F. Liewald, H. C. Ben-Ami, A. Gottschalk, and M. Treinin
The Conserved RIC-3 Coiled-Coil Domain Mediates Receptor-specific Interactions with Nicotinic Acetylcholine Receptors
Mol. Biol. Cell, March 1, 2009; 20(5): 1419 - 1427.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
N. K. Charlie, A. M. Thomure, M. A. Schade, and K. G. Miller
The Dunce cAMP Phosphodiesterase PDE-4 Negatively Regulates G{alpha}s-Dependent and G{alpha}s-Independent cAMP Pools in the Caenorhabditis elegans Synaptic Signaling Network
Genetics, May 1, 2006; 173(1): 111 - 130.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
N. K. Charlie, M. A. Schade, A. M. Thomure, and K. G. Miller
Presynaptic UNC-31 (CAPS) Is Required to Activate the G{alpha}s Pathway of the Caenorhabditis elegans Synaptic Signaling Network
Genetics, February 1, 2006; 172(2): 943 - 961.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. A. Bany, M.-Q. Dong, and M. R. Koelle
Genetic and Cellular Basis for Acetylcholine Inhibition of Caenorhabditis elegans Egg-Laying Behavior
J. Neurosci., September 3, 2003; 23(22): 8060 - 8069.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Zhu, J. S. Duerr, H. Varoqui, J. R. McManus, J. B. Rand, and J. D. Erickson
Analysis of Point Mutants in the Caenorhabditis elegans Vesicular Acetylcholine Transporter Reveals Domains Involved in Substrate Translocation
J. Biol. Chem., November 2, 2001; 276(45): 41580 - 41587.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online