Am J Physiol Cell Physiol Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 280: C621-C627, 2001;
0363-6143/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (82)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McArdle, A.
Right arrow Articles by Jackson, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McArdle, A.
Right arrow Articles by Jackson, M. J.
Vol. 280, Issue 3, C621-C627, March 2001

Contractile activity-induced oxidative stress: cellular origin and adaptive responses

A. McArdle, D. Pattwell, A. Vasilaki, R. D. Griffiths, and M. J. Jackson

Department of Medicine, University of Liverpool, Liverpool L69 3GA, United Kingdom

Previous studies have reported that oxidizing free radical species are generated during exercise, and there has been considerable interest in the potential effects of these on exercising tissues. We hypothesized that contracting skeletal muscle was a major source of oxidizing free radical species and that untrained skeletal muscle would adapt to the oxidative stress of a single short period of contractile activity by upregulation of the activity of cytoprotective proteins in the absence of overt cellular damage. Fifteen minutes of aerobic contractile activity was found to induce a rapid release of superoxide anions from mouse skeletal muscle in vivo, and studies with contracting cultured skeletal muscle myotubes confirmed that this was due to release from myocytes rather than other cell types present within muscle tissue in vivo. This increased oxidant production caused a rapid, transient reduction in muscle protein thiol content, followed by increases in the activities of superoxide dismutase and catalase and in content of heat shock proteins. These changes occurred in the absence of overt damage to the muscle cells.

superoxide; redox regulation; stress proteins


This article has been cited by other articles:


Home page
 J. Physiol.Home page
S. V. Brooks, A. Vasilaki, L. M. Larkin, A. McArdle, and M. J. Jackson
Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor {kappa}B activation
J. Physiol., August 15, 2008; 586(16): 3979 - 3990.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. M. Stary, B. J. Walsh, A. E. Knapp, D. Brafman, and M. C. Hogan
Elevation in heat shock protein 72 mRNA following contractions in isolated single skeletal muscle fibers
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R642 - R648.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. C. Lockhart and S. V. Brooks
Neutrophil accumulation following passive stretches contributes to adaptations that reduce contraction-induced skeletal muscle injury in mice
J Appl Physiol, April 1, 2008; 104(4): 1109 - 1115.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. C. Kayani, G. L. Close, M. J. Jackson, and A. McArdle
Prolonged treadmill training increases HSP70 in skeletal muscle but does not affect age-related functional deficits
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R568 - R576.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. R. Tupling, E. Bombardier, R. D. Stewart, C. Vigna, and A. E. Aqui
Muscle fiber type-specific response of Hsp70 expression in human quadriceps following acute isometric exercise
J Appl Physiol, December 1, 2007; 103(6): 2105 - 2111.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
A. V. Crowe, A. McArdle, F. McArdle, D. M. Pattwell, G. M. Bell, G. J. Kemp, J. M. Bone, R. D. Griffiths, and M. J. Jackson
Markers of oxidative stress in the skeletal muscle of patients on haemodialysis
Nephrol. Dial. Transplant., April 1, 2007; 22(4): 1177 - 1183.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. J. Jackson, D. Pye, and J. Palomero
The production of reactive oxygen and nitrogen species by skeletal muscle
J Appl Physiol, April 1, 2007; 102(4): 1664 - 1670.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Freyssenet
Energy sensing and regulation of gene expression in skeletal muscle
J Appl Physiol, February 1, 2007; 102(2): 529 - 540.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. Buttner, S. Mosig, A. Lechtermann, H. Funke, and F. C. Mooren
Exercise affects the gene expression profiles of human white blood cells
J Appl Physiol, January 1, 2007; 102(1): 26 - 36.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
F. R. Heinzel, Y. Luo, G. Dodoni, K. Boengler, F. Petrat, F. Di Lisa, H. de Groot, R. Schulz, and G. Heusch
Formation of reactive oxygen species at increased contraction frequency in rat cardiomyocytes
Cardiovasc Res, July 15, 2006; 71(2): 374 - 382.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. P. Morton, D. P. M. MacLaren, N. T. Cable, T. Bongers, R. D. Griffiths, I. T. Campbell, L. Evans, A. Kayani, A. McArdle, and B. Drust
Time course and differential responses of the major heat shock protein families in human skeletal muscle following acute nondamaging treadmill exercise
J Appl Physiol, July 1, 2006; 101(1): 176 - 182.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. S. Broome, A. C. Kayani, J. Palomero, W. H. Dillmann, R. Mestril, M. J. Jackson, and A. McArdle
Effect of lifelong overexpression of HSP70 in skeletal muscle on age-related oxidative stress and adaptation after nondamaging contractile activity
FASEB J, July 1, 2006; 20(9): 1549 - 1551.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. C. Gong, S. Arbogast, Z. Guo, J. Mathenia, W. Su, and M. B. Reid
Calcium-independent phospholipase A2 modulates cytosolic oxidant activity and contractile function in murine skeletal muscle cells
J Appl Physiol, February 1, 2006; 100(2): 399 - 405.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. G. Tidball
Inflammatory processes in muscle injury and repair
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R345 - R353.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F McArdle, S Spiers, H Aldemir, A Vasilaki, A Beaver, L Iwanejko, A McArdle, and M. J Jackson
Preconditioning of skeletal muscle against contraction-induced damage: the role of adaptations to oxidants in mice
J. Physiol., November 15, 2004; 561(1): 233 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. McArdle, J. van der Meulen, G. L. Close, D. Pattwell, H. Van Remmen, T. T. Huang, A. G. Richardson, C. J. Epstein, J. A. Faulkner, and M. J. Jackson
Role of mitochondrial superoxide dismutase in contraction-induced generation of reactive oxygen species in skeletal muscle extracellular space
Am J Physiol Cell Physiol, May 1, 2004; 286(5): C1152 - C1158.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Mak and G. E. Newton
Redox modulation of the inotropic response to dobutamine is impaired in patients with heart failure
Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H789 - H795.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. Medved, M. J. Brown, A. R. Bjorksten, and M. J. McKenna
Effects of intravenous N-acetylcysteine infusion on time to fatigue and potassium regulation during prolonged cycling exercise
J Appl Physiol, January 1, 2004; 96(1): 211 - 217.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. Pattwell, T. Ashton, A. McArdle, R. D. Griffiths, and M. J. Jackson
Ischemia and reperfusion of skeletal muscle lead to the appearance of a stable lipid free radical in the circulation
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2400 - H2404.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. McLoughlin, E. Mylona, T. A. Hornberger, K. A. Esser, and F. X. Pizza
Inflammatory cells in rat skeletal muscle are elevated after electrically stimulated contractions
J Appl Physiol, March 1, 2003; 94(3): 876 - 882.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. R. Speakman, C. Selman, J. S. McLaren, and E. J. Harper
Living Fast, Dying When? The Link between Aging and Energetics
J. Nutr., June 1, 2002; 132(6): 1583S - 1597.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Khassaf, R. B. Child, A. McArdle, D. A. Brodie, C. Esanu, and M. J. Jackson
Time course of responses of human skeletal muscle to oxidative stress induced by nondamaging exercise
J Appl Physiol, March 1, 2001; 90(3): 1031 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. X. Pizza, T. J. Koh, S. J. McGregor, and S. V. Brooks
Muscle inflammatory cells after passive stretches, isometric contractions, and lengthening contractions
J Appl Physiol, May 1, 2002; 92(5): 1873 - 1878.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online