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Am J Physiol Cell Physiol 280: C473-C480, 2001;
0363-6143/01 $5.00
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Vol. 280, Issue 3, C473-C480, March 2001

Effects of KCNQ channel blockers on K+ currents in vestibular hair cells

Katherine J. Rennie1, Tianxiang Weng1, and Manning J. Correia1,2

Departments of 1 Otolaryngology and 2 Physiology and Biophysics, The University of Texas Medical Branch, Galveston, Texas 77555-1063

Linopirdine and XE991, selective blockers of K+ channels belonging to the KCNQ family, were applied to hair cells isolated from gerbil vestibular system and to hair cells in slices of pigeon crista. In type II hair cells, both compounds inhibited a slowly activating, slowly inactivating component of the macroscopic current recruited at potentials above -60 mV. The dissociation constants for linopirdine and XE991 block were <5 µM. A similar component of the current was also blocked by 50 µM capsaicin in gerbil type II hair cells. All three drugs blocked a current component that showed steady-state inactivation and a biexponential inactivation with time constants of ~300 ms and 4 s. Linopirdine (10 µM) reduced inward currents through the low-voltage-activated K+ current in type I hair cells, but concentrations up to 200 µM had little effect on steady-state outward K+ current in these cells. These results suggest that KCNQ channels may be present in amniote vestibular hair cells.

delayed rectifier; potassium channel; pigeon; gerbil


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