Am J Physiol Cell Physiol AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 280: C265-C272, 2001;
0363-6143/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (36)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schrier, A. D.
Right arrow Articles by Barrett, P. Q.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schrier, A. D.
Right arrow Articles by Barrett, P. Q.
Vol. 280, Issue 2, C265-C272, February 2001

alpha 1H T-type Ca2+ channel is the predominant subtype expressed in bovine and rat zona glomerulosa

Andrew D. Schrier, Hongge Wang, Edmund M. Talley, Edward Perez-Reyes, and Paula Q. Barrett

Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908

The low voltage-activated (T-type) Ca2+ channel has been implicated in the regulation of aldosterone secretion from the adrenal zona glomerulosa by extracellular K+ levels, angiotensin II, and ACTH. However, the identity of the specific subtype mediating this regulation has not been determined. We utilized in situ hybridization to examine the distribution of three newly cloned members of the T-type Ca2+ channel family, alpha 1G, alpha 1H, and alpha 1I, in the rat and bovine adrenal gland. Substantial expression of only the mRNA transcript for the alpha 1H-subunit was detected in the zona glomerulosa of both rat and bovine. A much weaker expression signal was detected for the alpha 1H transcript in the zona fasciculata of bovine. Whole cell recordings of isolated bovine adrenal zona glomerulosa cells showed the native low voltage-activated current to be inhibited by NiCl2 with an IC50 of 6.4 ± 0.2 µM. Because the alpha 1H subtype exhibits similar NiCl2 sensitivity, we propose that the alpha 1H subtype is the predominant T-type Ca2+ channel present in the adrenal zona glomerulosa.

in situ hybridization; adrenal cortex; low voltage-activated calcium channels; nickel inhibition


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
H. Liu, J. A. Enyeart, and J. J. Enyeart
Potent Inhibition of Native TREK-1 K+ Channels by Selected Dihydropyridine Ca2+ Channel Antagonists
J. Pharmacol. Exp. Ther., October 1, 2007; 323(1): 39 - 48.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
V. Carabelli, A. Marcantoni, V. Comunanza, A. de Luca, J. Diaz, R. Borges, and E. Carbone
Chronic hypoxia up-regulates {alpha}1H T-type channels and low-threshold catecholamine secretion in rat chromaffin cells
J. Physiol., October 1, 2007; 584(1): 149 - 165.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. G. Garcia, A. M. Garcia-De-Diego, L. Gandia, R. Borges, and J. Garcia-Sancho
Calcium signaling and exocytosis in adrenal chromaffin cells.
Physiol Rev, October 1, 2006; 86(4): 1093 - 1131.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
A. Giancippoli, M. Novara, A. de Luca, P. Baldelli, A. Marcantoni, E. Carbone, and V. Carabelli
Low-Threshold Exocytosis Induced by cAMP-Recruited CaV3.2 ({alpha}1H) Channels in Rat Chromaffin Cells
Biophys. J., March 1, 2006; 90(5): 1830 - 1841.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Novara, P. Baldelli, D. Cavallari, V. Carabelli, A. Giancippoli, and E. Carbone
Exposure to cAMP and {beta}-adrenergic stimulation recruits CaV3 T-type channels in rat chromaffin cells through Epac cAMP-receptor proteins
J. Physiol., July 15, 2004; 558(2): 433 - 449.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. SPAT and L. HUNYADY
Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling Pathways
Physiol Rev, April 1, 2004; 84(2): 489 - 539.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
E. Perez-Reyes
Paradoxical Role of T-type Calcium Channels in Coronary Smooth Muscle
Mol. Interv., February 1, 2004; 4(1): 16 - 18.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C.-C. Chen, K. G. Lamping, D. W. Nuno, R. Barresi, S. J. Prouty, J. L. Lavoie, L. L. Cribbs, S. K. England, C. D. Sigmund, R. M. Weiss, et al.
Abnormal Coronary Function in Mice Deficient in {alpha}1H T-type Ca2+ Channels
Science, November 21, 2003; 302(5649): 1416 - 1418.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
E. Perez-Reyes
Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels
Physiol Rev, January 1, 2003; 83(1): 117 - 161.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J.-H. Lee, E.-G. Kim, B.-G. Park, K.-H. Kim, S.-K. Cha, I. D. Kong, J.-W. Lee, and S.-W. Jeong
Identification of T-Type alpha 1H Ca2+ Channels (Cav3.2) in Major Pelvic Ganglion Neurons
J Neurophysiol, June 1, 2002; 87(6): 2844 - 2850.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online