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Am J Physiol Cell Physiol 280: C265-C272, 2001;
0363-6143/01 $5.00
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Vol. 280, Issue 2, C265-C272, February 2001

alpha 1H T-type Ca2+ channel is the predominant subtype expressed in bovine and rat zona glomerulosa

Andrew D. Schrier, Hongge Wang, Edmund M. Talley, Edward Perez-Reyes, and Paula Q. Barrett

Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908

The low voltage-activated (T-type) Ca2+ channel has been implicated in the regulation of aldosterone secretion from the adrenal zona glomerulosa by extracellular K+ levels, angiotensin II, and ACTH. However, the identity of the specific subtype mediating this regulation has not been determined. We utilized in situ hybridization to examine the distribution of three newly cloned members of the T-type Ca2+ channel family, alpha 1G, alpha 1H, and alpha 1I, in the rat and bovine adrenal gland. Substantial expression of only the mRNA transcript for the alpha 1H-subunit was detected in the zona glomerulosa of both rat and bovine. A much weaker expression signal was detected for the alpha 1H transcript in the zona fasciculata of bovine. Whole cell recordings of isolated bovine adrenal zona glomerulosa cells showed the native low voltage-activated current to be inhibited by NiCl2 with an IC50 of 6.4 ± 0.2 µM. Because the alpha 1H subtype exhibits similar NiCl2 sensitivity, we propose that the alpha 1H subtype is the predominant T-type Ca2+ channel present in the adrenal zona glomerulosa.

in situ hybridization; adrenal cortex; low voltage-activated calcium channels; nickel inhibition


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