Am J Physiol Cell Physiol Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 279: C2004-C2010, 2000;
0363-6143/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (15)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Knöferl, M. W.
Right arrow Articles by Chaudry, I. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Knöferl, M. W.
Right arrow Articles by Chaudry, I. H.
Vol. 279, Issue 6, C2004-C2010, December 2000

Severe hypoxemia in the absence of blood loss causes a gender dimorphic immune response

Markus W. Knöferl1, Doraid Jarrar2, Martin G. Schwacha2, Martin K. Angele3, William G. Cioffi4, Kirby I. Bland2, and Irshad H. Chaudry2

4 Department of Surgery, Center for Surgical Research, Brown University School of Medicine and Rhode Island Hospital, Providence, Rhode Island 02903; 2 Department of Surgery, School of Medicine, University of Alabama-Birmingham, Birmingham, Alabama 35294; 1 Department of Trauma-Surgery, University of Ulm, 89075 Ulm, Germany; and 3 Department of Surgery, Klinikum Grosshadern, 81377 Munich, Germany

A gender dimorphic immune response has been observed after trauma and severe hemorrhage, a condition believed to be associated with tissue hypoxia. Although studies have shown that hypoxemia per se in males causes a systemic inflammatory response, it is unclear if the inflammatory response to hypoxemia exhibits gender dimorphic characteristics. To study this, male and female C3H/HeN mice in the proestrus state of the estrous cycle were subjected to hypoxemia (95% N2-5% O2) or sham hypoxemia (room air) for 60 min. Later (2 h), plasma interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha levels were determined along with splenic immune responses. Plasma IL-6 and TNF-alpha concentrations after hypoxemia were significantly increased in males but not in females. Splenocyte proliferation was depressed in males after hypoxemia but not in females. A shift toward an immunosuppressive Th-2 cytokine profile was observed in males after hypoxemia [decreased interferon-gamma (Th-1) and increased IL-10 (Th-2)], whereas no such shift was observed in females. Splenic macrophage IL-6, IL-10, and IL-12 production were suppressed in males after hypoxemia; however, such suppression was not observed in females. These findings therefore indicate that a gender dimorphic immune response also exists after hypoxemia in the absence of blood loss and tissue trauma, similar to trauma-hemorrhage. Furthermore, because no systemic inflammatory response or alterations in T lymphocyte or macrophage functions are observed in proestrus females but such parameters are markedly altered after severe hypoxemia in males, these studies indicate that proestrus females can tolerate hypoxemia better than males.

rodent; inflammation; cytokines; sex steroids; proestrus


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
B. M. Thobe, M. Frink, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry
Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia
Am J Physiol Cell Physiol, September 1, 2006; 291(3): C476 - C482.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
C. C. Blackwell, S. M. Moscovis, A. E. Gordon, O. M. Al Madani, S. T. Hall, M. Gleeson, R. J. Scott, J. Roberts-Thomson, D. M. Weir, and A. Busuttil
Cytokine responses and sudden infant death syndrome: genetic, developmental, and environmental risk factors
J. Leukoc. Biol., December 1, 2005; 78(6): 1242 - 1254.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
J. Mehilli, G. Ndrepepa, A. Kastrati, S. G. Nekolla, C. Markwardt, H. Bollwein, J. Pache, S. Martinoff, J. Dirschinger, M. Schwaiger, et al.
Gender and myocardial salvage after reperfusion treatment in acute myocardial infarction
J. Am. Coll. Cardiol., March 15, 2005; 45(6): 828 - 831.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
Y. Yokoyama, W. C. Kitchens, B. Toth, M. G. Schwacha, L. W. Rue III, K. I. Bland, and I. H. Chaudry
Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage
Am J Physiol Gastrointest Liver Physiol, June 1, 2004; 286(6): G942 - G946.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. W. Knoferl, M. K. Angele, R. A. Catania, M. D. Diodato, K. I. Bland, and I. H. Chaudry
Immunomodulatory effects of dehydroepiandrosterone in proestrus female mice after trauma-hemorrhage
J Appl Physiol, August 1, 2003; 95(2): 529 - 535.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Tesfaigzi, K. Rudolph, M. J. Fischer, and C. A. Conn
Bcl-2 mediates sex-specific differences in recovery of mice from LPS-induced signs of sickness independent of IL-6
J Appl Physiol, November 1, 2001; 91(5): 2182 - 2189.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. W. Knoferl, M. G. Schwacha, D. Jarrar, M. K. Angele, K. Fragoza, K. I. Bland, and I. H. Chaudry
Estrogen pretreatment protects males against hypoxia-induced immune depression
Am J Physiol Cell Physiol, May 1, 2002; 282(5): C1087 - C1092.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online