Am J Physiol Cell Physiol Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 279: C906-C914, 2000;
0363-6143/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (63)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rahman, A.
Right arrow Articles by Malik, A. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rahman, A.
Right arrow Articles by Malik, A. B.
Vol. 279, Issue 4, C906-C914, October 2000

Protein kinase C-zeta mediates TNF-alpha -induced ICAM-1 gene transcription in endothelial cells

Arshad Rahman, Khandaker N. Anwar, and Asrar B. Malik

Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612

We addressed the role of protein kinase C (PKC) isozymes in mediating tumor necrosis factor-alpha (TNF-alpha )-induced oxidant generation in endothelial cells, a requirement for nuclear factor-kappa B (NF-kappa B) activation and intercellular adhesion molecule-1 (ICAM-1) gene transcription. Depletion of the conventional (c) and novel (n) PKC isozymes following 24 h exposure of human pulmonary artery endothelial (HPAE) cells with the phorbol ester, phorbol 12-myristate 13-acetate (500 nM), failed to prevent TNF-alpha -induced oxidant generation. In contrast, inhibition of PKC-zeta synthesis by the antisense oligonucleotide prevented the oxidant generation following the TNF-alpha stimulation. We observed that PKC-zeta also induced the TNF-alpha -induced NF-kappa B binding to the ICAM-1 promoter and the resultant ICAM-1 gene transcription. We showed that expression of the dominant negative mutant of PKC-zeta prevented the TNF-alpha -induced ICAM-1 promoter activity, whereas overexpression of the wild-type PKC-zeta augmented the response. These data imply a critical role for the PKC-zeta isozyme in regulating TNF-alpha -induced oxidant generation and in signaling the activation of NF-kappa B and ICAM-1 transcription in endothelial cells.

protein kinase C isoforms; oxidants; nuclear factor-kappa B; intercellular adhesion molecule-1; endothelium


This article has been cited by other articles:


Home page
 Cancer Res.Home page
G. S. Thomas, L. Zhang, K. Blackwell, and H. Habelhah
Phosphorylation of TRAF2 within Its RING Domain Inhibits Stress-Induced Cell Death by Promoting IKK and Suppressing JNK Activation
Cancer Res., April 15, 2009; 69(8): 3665 - 3672.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
N. Lerner-Marmarosh, T. Miralem, P. E. M. Gibbs, and M. D. Maines
Regulation of TNF-{alpha}-activated PKC-{zeta} signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase
FASEB J, December 1, 2007; 21(14): 3949 - 3962.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J.-H. Parmentier, C. Zhang, A. Estes, S. Schaefer, and K. U. Malik
Essential role of PKC-{zeta} in normal and angiotensin II-accelerated neointimal growth after vascular injury
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1602 - H1613.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. Mehta and A. B. Malik
Signaling Mechanisms Regulating Endothelial Permeability
Physiol Rev, January 1, 2006; 86(1): 279 - 367.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-K. Min, Y.-M. Kim, S. W. Kim, M.-C. Kwon, Y.-Y. Kong, I. K. Hwang, M. H. Won, J. Rho, and Y.-G. Kwon
TNF-Related Activation-Induced Cytokine Enhances Leukocyte Adhesiveness: Induction of ICAM-1 and VCAM-1 via TNF Receptor-Associated Factor and Protein Kinase C-Dependent NF-{kappa}B Activation in Endothelial Cells
J. Immunol., July 1, 2005; 175(1): 531 - 540.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Minhajuddin, F. Fazal, K. M. Bijli, Md. R. Amin, and A. Rahman
Inhibition of Mammalian Target of Rapamycin Potentiates Thrombin-Induced Intercellular Adhesion Molecule-1 Expression by Accelerating and Stabilizing NF-{kappa}B Activation in Endothelial Cells
J. Immunol., May 1, 2005; 174(9): 5823 - 5829.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
Z. Biao, X. Zhanggang, J. Hao, M. Changhong, and C. Jing
The In Vitro Effect of Desflurane Preconditioning on Endothelial Adhesion Molecules and mRNA Expression
Anesth. Analg., April 1, 2005; 100(4): 1007 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. Rask-Madsen and G. L. King
Proatherosclerotic Mechanisms Involving Protein Kinase C in Diabetes and Insulin Resistance
Arterioscler Thromb Vasc Biol, March 1, 2005; 25(3): 487 - 496.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. Tang, B. Low, S. A. Rutherford, and Q. Hao
Thrombin induces endocytosis of endoglin and type-II TGF-{beta} receptor and down-regulation of TGF-{beta} signaling in endothelial cells
Blood, March 1, 2005; 105(5): 1977 - 1985.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C.-H. Woo, J.-H. Lim, and J.-H. Kim
VCAM-1 upregulation via PKC{delta}-p38 kinase-linked cascade mediates the TNF-{alpha}-induced leukocyte adhesion and emigration in the lung airway epithelium
Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L307 - L316.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Rahman, K. N. Anwar, Mohd. Minhajuddin, K. M. Bijli, K. Javaid, A. L. True, and A. B. Malik
cAMP targeting of p38 MAP kinase inhibits thrombin-induced NF-{kappa}B activation and ICAM-1 expression in endothelial cells
Am J Physiol Lung Cell Mol Physiol, November 1, 2004; 287(5): L1017 - L1024.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Md. R. Abid, I. G. Schoots, K. C. Spokes, S.-Q. Wu, C. Mawhinney, and W. C. Aird
Vascular Endothelial Growth Factor-mediated Induction of Manganese Superoxide Dismutase Occurs through Redox-dependent Regulation of Forkhead and I{kappa}B/NF-{kappa}B
J. Biol. Chem., October 15, 2004; 279(42): 44030 - 44038.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
X. Li, C. N. Hahn, M. Parsons, J. Drew, M. A. Vadas, and J. R. Gamble
Role of protein kinase C{zeta} in thrombin-induced endothelial permeability changes: inhibition by angiopoietin-1
Blood, September 15, 2004; 104(6): 1716 - 1724.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
S. A. Vielma, M. Mironova, J.-R. Ku, and M. F. Lopes-Virella
Oxidized LDL further enhances expression of adhesion molecules in Chlamydophila pneumoniae-infected endothelial cells
J. Lipid Res., May 1, 2004; 45(5): 873 - 880.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
T. Minami, A. Sugiyama, S.-Q. Wu, R. Abid, T. Kodama, and W. C. Aird
Thrombin and Phenotypic Modulation of the Endothelium
Arterioscler Thromb Vasc Biol, January 1, 2004; 24(1): 41 - 53.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Gertzberg, P. Neumann, V. Rizzo, and A. Johnson
NAD(P)H oxidase mediates the endothelial barrier dysfunction induced by TNF-{alpha}
Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L37 - L48.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. D. Savkovic, A. Koutsouris, and G. Hecht
PKC{zeta} participates in activation of inflammatory response induced by enteropathogenic E. coli
Am J Physiol Cell Physiol, September 1, 2003; 285(3): C512 - C521.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
K. Javaid, A. Rahman, K. N. Anwar, R. S. Frey, R. D. Minshall, and A. B. Malik
Tumor Necrosis Factor-{alpha} Induces Early-Onset Endothelial Adhesivity by Protein Kinase C{zeta}-Dependent Activation of Intercellular Adhesion Molecule-1
Circ. Res., May 30, 2003; 92(10): 1089 - 1097.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. A. Vielma, G. Krings, and M. F. Lopes-Virella
Chlamydophila pneumoniae Induces ICAM-1 Expression in Human Aortic Endothelial Cells via Protein Kinase C-Dependent Activation of Nuclear Factor-{kappa}B
Circ. Res., May 30, 2003; 92(10): 1130 - 1137.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
W. C. Aird
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
Blood, May 15, 2003; 101(10): 3765 - 3777.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
J Berkes, V K Viswanathan, S D Savkovic, and G Hecht
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation
Gut, March 1, 2003; 52(3): 439 - 451.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. Siflinger-Birnboim and A. Johnson
Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury
Am J Physiol Lung Cell Mol Physiol, March 1, 2003; 284(3): L435 - L451.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
R. S. Frey, A. Rahman, J. C. Kefer, R. D. Minshall, and A. B. Malik
PKC{zeta} Regulates TNF-{alpha}-Induced Activation of NADPH Oxidase in Endothelial Cells
Circ. Res., May 17, 2002; 90(9): 1012 - 1019.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
N. Xu, X.-P. Gao, R. D. Minshall, A. Rahman, and A. B. Malik
Time-dependent reversal of sepsis-induced PMN uptake and lung vascular injury by expression of CD18 antagonist
Am J Physiol Lung Cell Mol Physiol, April 1, 2002; 282(4): L796 - L802.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online