Am J Physiol Cell Physiol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


Am J Physiol Cell Physiol 279: C611-C618, 2000;
0363-6143/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (68)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frontera, W. R.
Right arrow Articles by Roubenoff, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frontera, W. R.
Right arrow Articles by Roubenoff, R.
Vol. 279, Issue 3, C611-C618, September 2000

Skeletal muscle fiber quality in older men and women

Walter R. Frontera1,2, Dongwon Suh2, Lisa S. Krivickas2, Virginia A. Hughes1, Richard Goldstein2, and Ronenn Roubenoff1

1 Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111; and 2 Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, Massachusetts 02114

Whole muscle strength and cross-sectional area (WMCSA), and contractile properties of chemically skinned segments from single fibers of the quadriceps were studied in 7 young men (YM, 36.5 ± 3.0 yr), 12 older men (OM, 74.4 ± 5.9 yr), and 12 older women (OW, 72.1 ± 4.3 yr). WMCSA was smaller in OM compared with YM (56.1 ± 10.1 vs. 79.7 ± 13.1 cm2; P = 0.031) and in OW (44.9 ± 7.5; P < 0.003) compared with OM. Age-related, but not sex-related, differences in strength were eliminated after adjusting for WMCSA. Maximal force was measured in 552 type I and 230 type IIA fibers. Fibers from YM (type I = 725 ± 221; type IIA = 792 ± 271 µN) were stronger (P < 0.001) than fibers from OM (I = 505 ± 179; IIA = 577 ± 262 µN) even after correcting for size. Type IIA fibers were stronger (P < 0.005) than type I fibers in YM and OM but not in OW (I = 472 ± 154; IIA = 422 ± 97 µN). Sex-related differences in type I and IIA fibers were dependent on fiber size. In conclusion, differences in WMCSA explain age-related differences in strength. An intrinsic defect in contractile proteins could explain weakness in single fibers from OM. Sex-related differences exist at the whole muscle and single fiber levels.

sarcopenia; chemically skinned segments of single fibers; aging; specific force


This article has been cited by other articles:


Home page
J. Appl. Physiol.Home page
L. H. Chung, D. M. Callahan, and J. A. Kent-Braun
Age-related resistance to skeletal muscle fatigue is preserved during ischemia
J Appl Physiol, November 1, 2007; 103(5): 1628 - 1635.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
R. Moreno Lima, B. S. de Abreu, P. Gentil, T. C. de Lima Lins, D. Grattapaglia, R. W. Pereira, and R. J. de Oliveira
Lack of Association Between Vitamin D Receptor Genotypes and Haplotypes With Fat-Free Mass in Postmenopausal Brazilian Women
J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2007; 62(9): 966 - 972.
[Abstract] [Full Text] [PDF]


Home page
J. Neurophysiol.Home page
B. K. Barry, M. A. Pascoe, M. Jesunathadas, and R. M. Enoka
Rate Coding Is Compressed But Variability Is Unaltered for Motor Units in a Hand Muscle of Old Adults
J Neurophysiol, May 1, 2007; 97(5): 3206 - 3218.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
C. J. McNeil, A. A. Vandervoort, and C. L. Rice
Peripheral impairments cause a progressive age-related loss of strength and velocity-dependent power in the dorsiflexors
J Appl Physiol, May 1, 2007; 102(5): 1962 - 1968.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
M. T. Korhonen, A. Cristea, M. Alen, K. Hakkinen, S. Sipila, A. Mero, J. T. Viitasalo, L. Larsson, and H. Suominen
Aging, muscle fiber type, and contractile function in sprint-trained athletes
J Appl Physiol, September 1, 2006; 101(3): 906 - 917.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
F. Haddad and G. R. Adams
Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy
J Appl Physiol, April 1, 2006; 100(4): 1188 - 1203.
[Abstract] [Full Text] [PDF]


Home page
Exp PhysiolHome page
G. F. Martel, S. M. Roth, F. M. Ivey, J. T. Lemmer, B. L. Tracy, D. E. Hurlbut, E. J. Metter, B. F. Hurley, and M. A. Rogers
Age and sex affect human muscle fibre adaptations to heavy-resistance strength training
Exp Physiol, March 1, 2006; 91(2): 457 - 464.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
P. Szentesi, M. A. Bekedam, B. J. van Beek-Harmsen, W. J. van der Laarse, R. Zaremba, A. Boonstra, F. C. Visser, and G. J. M. Stienen
Depression of force production and ATPase activity in different types of human skeletal muscle fibers from patients with chronic heart failure
J Appl Physiol, December 1, 2005; 99(6): 2189 - 2195.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
J. M. Thom, C. I. Morse, K. M. Birch, and M. V. Narici
Triceps Surae Muscle Power, Volume, and Quality in Older Versus Younger Healthy Men
J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2005; 60(9): 1111 - 1117.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
C. I. Morse, J. M. Thom, N. D. Reeves, K. M. Birch, and M. V. Narici
In vivo physiological cross-sectional area and specific force are reduced in the gastrocnemius of elderly men
J Appl Physiol, September 1, 2005; 99(3): 1050 - 1055.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
K. R. Short, J. L. Vittone, M. L. Bigelow, D. N. Proctor, J. M. Coenen-Schimke, P. Rys, and K. S. Nair
Changes in myosin heavy chain mRNA and protein expression in human skeletal muscle with age and endurance exercise training
J Appl Physiol, July 1, 2005; 99(1): 95 - 102.
[Abstract] [Full Text] [PDF]


Home page
J. Physiol.Home page
Z.-M. Wang, Z. Zheng, M. L. Messi, and O. Delbono
Extension and magnitude of denervation in skeletal muscle from ageing mice
J. Physiol., June 15, 2005; 565(3): 757 - 764.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
E. Simoneau, A. Martin, and J. Van Hoecke
Muscular Performances at the Ankle Joint in Young and Elderly Men
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2005; 60(4): 439 - 447.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Coll. Nutr.Home page
H. C. Dreyer and E. Volpi
Role of Protein and Amino Acids in the Pathophysiology and Treatment of Sarcopenia
J. Am. Coll. Nutr., April 1, 2005; 24(2): 140S - 145S.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
J. K. Petrella, J.-s. Kim, S. C. Tuggle, S. R. Hall, and M. M. Bamman
Age differences in knee extension power, contractile velocity, and fatigability
J Appl Physiol, January 1, 2005; 98(1): 211 - 220.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
C. I. Morse, J. M. Thom, K. M. Birch, and M. V. Narici
Tendon elongation influences the amplitude of interpolated doublets in the assessment of activation in elderly men
J Appl Physiol, January 1, 2005; 98(1): 221 - 226.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
B. K. Barry and R. G. Carson
The Consequences of Resistance Training for Movement Control in Older Adults
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2004; 59(7): M730 - M754.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
D. A. Lowe, G. L. Warren, L. M. Snow, L. V. Thompson, and D. D. Thomas
Muscle activity and aging affect myosin structural distribution and force generation in rat fibers
J Appl Physiol, February 1, 2004; 96(2): 498 - 506.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
M. V. Narici, C. N. Maganaris, N. D. Reeves, and P. Capodaglio
Effect of aging on human muscle architecture
J Appl Physiol, December 1, 2003; 95(6): 2229 - 2234.
[Abstract] [Full Text]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
R. Roubenoff
Sarcopenia: Effects on Body Composition and Function
J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2003; 58(11): M1012 - 1017.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
T. J. Doherty
Invited Review: Aging and sarcopenia
J Appl Physiol, October 1, 2003; 95(4): 1717 - 1727.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
R. T. Hepple, J. L. Hagen, D. J. Krause, and C. C. Jackson
Aerobic power declines with aging in rat skeletal muscles perfused at matched convective O2 delivery
J Appl Physiol, February 1, 2003; 94(2): 744 - 751.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
J. J. Widrick, G. F. Maddalozzo, D. Lewis, B. A. Valentine, D. P. Garner, J. E. Stelzer, T. C. Shoepe, and C. M. Snow
Morphological and Functional Characteristics of Skeletal Muscle Fibers From Hormone-replaced and Nonreplaced Postmenopausal Women
J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2003; 58(1): B3 - 10.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. J. Widrick, J. E. Stelzer, T. C. Shoepe, and D. P. Garner
Functional properties of human muscle fibers after short-term resistance exercise training
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R408 - R416.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
D. A. Lowe, D. D. Thomas, and L. V. Thompson
Force generation, but not myosin ATPase activity, declines with age in rat muscle fibers
Am J Physiol Cell Physiol, July 1, 2002; 283(1): C187 - C192.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Endocrinol. Metab.Home page
I. Sinha-Hikim, J. Artaza, L. Woodhouse, N. Gonzalez-Cadavid, A. B. Singh, M. I. Lee, T. W. Storer, R. Casaburi, R. Shen, and S. Bhasin
Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy
Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E154 - E164.
[Abstract] [Full Text] [PDF]


Home page
J. Gerontol. A Biol. Sci. Med. Sci.Home page
S. Trappe, D. Williamson, and M. Godard
Maintenance of Whole Muscle Strength and Size Following Resistance Training in Older Men
J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2002; 57(4): B138 - 143.
[Abstract] [Full Text] [PDF]


Home page
J. Histochem. Cytochem.Home page
N. da Costa, R. Blackley, H. Alzuherri, and K.-C. Chang
Quantifying the Temporospatial Expression of Postnatal Porcine Skeletal Myosin Heavy Chain Genes
J. Histochem. Cytochem., March 1, 2002; 50(3): 353 - 364.
[Abstract] [Full Text] [PDF]


Home page
J. Appl. Physiol.Home page
C. S. Klein, C. L. Rice, and G. D. Marsh
Normalized force, activation, and coactivation in the arm muscles of young and old men
J Appl Physiol, September 1, 2001; 91(3): 1341 - 1349.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Cell Physiol.Home page
S. Trappe, M. Godard, P. Gallagher, C. Carroll, G. Rowden, and D. Porter
Resistance training improves single muscle fiber contractile function in older women
Am J Physiol Cell Physiol, August 1, 2001; 281(2): C398 - C406.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online