Am J Physiol Cell Physiol Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 279: C578-C586, 2000;
0363-6143/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (37)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Steppich, B.
Right arrow Articles by Ziegler-Heitbrock, H. W. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Steppich, B.
Right arrow Articles by Ziegler-Heitbrock, H. W. L.
Vol. 279, Issue 3, C578-C586, September 2000

Selective mobilization of CD14+CD16+ monocytes by exercise

Birgit Steppich1, Farshid Dayyani1, Rudolf Gruber2, Reinhard Lorenz3, Matthias Mack2, and H. W. Löms Ziegler-Heitbrock1

1 Institute for Immunology, 2 Medical Policlinic, Klinikum Innenstadt, and 3 Institute for Prophylaxis and Epidemiology of Cardiovascular Disease, University of Munich, 80336 Munich, Germany

Strenuous, anaerobic exercise leads to an increase of leukocytes that are mobilized from the marginal pool. We have analyzed in human peripheral blood the effect of exercise on the number of CD14+CD16+ monocytes as determined by two-color immunofluorescence and flow cytometry. We show herein that this type of monocyte responds with a dramatic up to 4.8-fold increase. Mobilization does not occur after 1 min at 100 or 200 W but 1 min at 400 W leads to a twofold increase of the CD14+CD16+ monocytes immediately after exercise. The numbers remain high at 5 min and gradually decrease to reach the initial level at 20 min postexercise. After 20 min of rest, the CD14+CD16+ monocytes can be mobilized again by a second exercise. The CD14+CD16+ monocytes appear to be mobilized from the marginal pool where they preferentially home because of a higher expression of adhesion molecules like CD11d and very late antigen-4. Exercise goes along with an increase of catecholamines, and mobilization of the CD14+CD16+ monocytes can be substantially reduced by treatment of donors with the beta -adrenergic receptor blocker propranolol. Mobilization of CD14+CD16+ monocytes by a catecholamine-dependent mechanism may contribute to the increase of these cells in various clinical conditions.

glucocorticoid; marginal pool; stress


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
E. Shantsila and G. Y.H. Lip
Monocyte Diversity in Myocardial Infarction.
J. Am. Coll. Cardiol., July 7, 2009; 54(2): 139 - 142.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. A. Selkirk, T. M. McLellan, H. E. Wright, and S. G. Rhind
Expression of intracellular cytokines, HSP72, and apoptosis in monocyte subsets during exertional heat stress in trained and untrained individuals
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R575 - R586.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
K. L. Timmerman, M. G. Flynn, P. M. Coen, M. M. Markofski, and B. D. Pence
Exercise training-induced lowering of inflammatory (CD14+CD16+) monocytes: a role in the anti-inflammatory influence of exercise?
J. Leukoc. Biol., November 1, 2008; 84(5): 1271 - 1278.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C. Auffray, D. Fogg, M. Garfa, G. Elain, O. Join-Lambert, S. Kayal, S. Sarnacki, A. Cumano, G. Lauvau, and F. Geissmann
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
Science, August 3, 2007; 317(5838): 666 - 670.
[Abstract] [Full Text] [PDF]

Home page
 AMERICAN JOURNAL OF LIFESTYLE MEDICINEHome page
M. G. Flynn, B. K. McFarlin, and M. M. Markofski
State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training
American Journal of Lifestyle Medicine, May 1, 2007; 1(3): 220 - 235.
[Abstract] [PDF]

Home page
 J. Leukoc. Biol.Home page
L. Ziegler-Heitbrock
The CD14+ CD16+ blood monocytes: their role in infection and inflammation
J. Leukoc. Biol., March 1, 2007; 81(3): 584 - 592.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
F. I. L. Clanchy, A. C. Holloway, R. Lari, P. U. Cameron, and J. A. Hamilton
Detection and properties of the human proliferative monocyte subpopulation
J. Leukoc. Biol., April 1, 2006; 79(4): 757 - 766.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. I Lancaster, Q. Khan, P. Drysdale, F. Wallace, A. E Jeukendrup, M. T Drayson, and M. Gleeson
The physiological regulation of toll-like receptor expression and function in humans
J. Physiol., March 15, 2005; 563(3): 945 - 955.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
T. Vassilakopoulos, C. Roussos, and S. Zakynthinos
The immune response to resistive breathing
Eur. Respir. J., December 1, 2004; 24(6): 1033 - 1043.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. Rivas-Carvalho, M. A. Meraz-Rios, L. Santos-Argumedo, S. Bajana, G. Soldevila, M. E. Moreno-Garcia, and C. Sanchez-Torres
CD16+ human monocyte-derived dendritic cells matured with different and unrelated stimuli promote similar allogeneic Th2 responses: regulation by pro- and anti-inflammatory cytokines
Int. Immunol., September 1, 2004; 16(9): 1251 - 1263.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Crowe, T. Zhu, and W. A. Muller
The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection
J. Leukoc. Biol., November 1, 2003; 74(5): 635 - 641.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
P. Ancuta, R. Rao, A. Moses, A. Mehle, S. K. Shaw, F. W. Luscinskas, and D. Gabuzda
Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes
J. Exp. Med., June 16, 2003; 197(12): 1701 - 1707.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Vassilakopoulos, P. Katsaounou, M.-H. Karatza, A. Kollintza, S. Zakynthinos, and C. Roussos
Strenuous Resistive Breathing Induces Plasma Cytokines: Role of Antioxidants and Monocytes
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1572 - 1578.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
J. M. Kittner, R. Jacobs, C. R. Pawlak, C. J. Heijnen, M. Schedlowski, and R. E. Schmidt
Adrenaline-induced immunological changes are altered in patients with rheumatoid arthritis
Rheumatology, September 1, 2002; 41(9): 1031 - 1039.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. A. Febbraio, R. L. Starkie, S. G. Rhind, and P. N. Shek
The Cellular Origin of Plasma Cytokine Expression After Acute Exercise
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1253 - R1257.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
K.-U. Belge, F. Dayyani, A. Horelt, M. Siedlar, M. Frankenberger, B. Frankenberger, T. Espevik, and L. Ziegler-Heitbrock
The Proinflammatory CD14+CD16+DR++ Monocytes Are a Major Source of TNF
J. Immunol., April 1, 2002; 168(7): 3536 - 3542.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. G. Rhind, J. W. Castellani, I. K. M. Brenner, R. J. Shephard, J. Zamecnik, S. J. Montain, A. J. Young, and P. N. Shek
Intracellular monocyte and serum cytokine expression is modulated by exhausting exercise and cold exposure
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R66 - R75.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online