Am J Physiol Cell Physiol AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 279: C1-C18, 2000;
0363-6143/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (43)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rao, S.
Right arrow Articles by Verkman, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rao, S.
Right arrow Articles by Verkman, A. S.
Vol. 279, Issue 1, C1-C18, July 2000

INVITED REVIEW
Analysis of organ physiology in transgenic mice

Shobha Rao and A. S. Verkman

Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0521

The increasing availability of transgenic mouse models of gene deletion and human disease has mandated the development of creative approaches to characterize mouse phenotype. The mouse presents unique challenges to phenotype analysis because of its small size, habits, and inability to verbalize clinical symptoms. This review describes strategies to study mouse organ physiology, focusing on the cardiovascular, pulmonary, renal, gastrointestinal, and neurobehavioral systems. General concerns about evaluating mouse phenotype studies are discussed. Monitoring and anesthesia methods are reviewed, with emphasis on the feasibility and limitations of noninvasive and invasive procedures to monitor physiological parameters, do cannulations, and perform surgical procedures. Examples of phenotype studies are cited to demonstrate the practical applications and limitations of the measurement methods. The repertoire of phenotype analysis methods reviewed here should be useful to investigators involved in or contemplating the use of mouse models.

rodent; surgery; anesthesia; cardiovascular; lung; kidney; brain


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
A. Rippe, C. Rippe, K. Sward, and B. Rippe
Disproportionally low clearance of macromolecules from the plasma to the peritoneal cavity in a mouse model of peritoneal dialysis
Nephrol. Dial. Transplant., January 1, 2007; 22(1): 88 - 95.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. P. Massett and B. C. Berk
Strain-dependent differences in responses to exercise training in inbred and hybrid mice
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R1006 - R1013.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. E. Markhus and H. Wiig
Isolation of interstitial fluid from skeletal muscle and subcutis in mice using a wick method
Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2085 - H2090.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. J. A. Janssen, T. De Celle, J. J. M. Debets, A. E. Brouns, M. F. Callahan, and T. L. Smith
Effects of anesthetics on systemic hemodynamics in mice
Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1618 - H1624.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. Glaab, W. Mitzner, A. Braun, H. Ernst, R. Korolewitz, J. M. Hohlfeld, N. Krug, and H. G. Hoymann
Repetitive measurements of pulmonary mechanics to inhaled cholinergic challenge in spontaneously breathing mice
J Appl Physiol, September 1, 2004; 97(3): 1104 - 1111.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Brommage
Validation and calibration of DEXA body composition in mice
Am J Physiol Endocrinol Metab, September 1, 2003; 285(3): E454 - E459.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Z. Borok and A. S. Verkman
Lung Edema Clearance: 20 Years of Progress: Invited Review: Role of aquaporin water channels in fluid transport in lung and airways
J Appl Physiol, December 1, 2002; 93(6): 2199 - 2206.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
O. Devuyst and W. B. Guggino
Chloride channels in the kidney: lessons learned from knockout animals
Am J Physiol Renal Physiol, December 1, 2002; 283(6): F1176 - F1191.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. N. Lorenz
A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1565 - R1582.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Jayaraman, Y. Song, and A. S. Verkman
Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea
Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1504 - C1511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Renolleau, S. Dauger, F. Autret, G. Vardon, C. Gaultier, and J. Gallego
Maturation of baseline breathing and of hypercapnic and hypoxic ventilatory responses in newborn mice
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1746 - R1753.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. J. Seward, J. C. Haney, M. A. Rudnicki, and S. J. Swoap
bHLH transcription factor MyoD affects myosin heavy chain expression pattern in a muscle-specific fashion
Am J Physiol Cell Physiol, February 1, 2001; 280(2): C408 - C413.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online