| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Institute of Cybernetics and 2 Laboratory of Bioenergetics, Institute of Chemical and Biological Physics, Tallinn, Estonia; and 3 Joseph Fourier University, BP 53X-38 041 Grenoble Cedex, France
The purpose of this study is to investigate theoretically which intracellular factors may be important for regulation of mitochondrial respiration in working heart cells in vivo. We have developed a model that describes quantitatively the published experimental data on dependence of the rate of oxygen consumption and metabolic state of working isolated perfused rat heart on workload over its physiological range (Williamson JR, Ford G, Illingworth J, Safer B. Circ Res 38, Suppl I, I39-I51, 1976). Analysis of this model shows that for phosphocreatine, creatine, and ATP the equilibrium assumption is an acceptable approximation with respect to their diffusion in the intracellular bulk water phase. However, the ADP concentration changes in the contraction cycle in a nonequilibrium workload-dependent manner, showing the existence of the intracellular concentration gradients. The model shows that workload-dependent alteration of ADP concentration in the compartmentalized creatine kinase system may be taken, together with the changes in Pi concentration, to be among the major components of the metabolic feedback signal for regulation of respiration in muscle cells.
compartmentation; adenosine diphosphate; creatine kinase; metabolic oscillations; mathematical modeling
This article has been cited by other articles:
|
|
 |
|
  M. Vendelin and R. Birkedal Anisotropic diffusion of fluorescently labeled ATP in rat cardiomyocytes determined by raster image correlation spectroscopy Am J Physiol Cell Physiol, November 1, 2008; 295(5): C1302 - C1315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Wu, E. Y. Zhang, J. Zhang, R. J. Bache, and D. A. Beard Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts J. Physiol., September 1, 2008; 586(17): 4193 - 4208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. G. M. van Beek Adenine nucleotide-creatine-phosphate module in myocardial metabolic system explains fast phase of dynamic regulation of oxidative phosphorylation Am J Physiol Cell Physiol, September 1, 2007; 293(3): C815 - C829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Wu, J. A. L. Jeneson, and D. A. Beard Oxidative ATP synthesis in skeletal muscle is controlled by substrate feedback Am J Physiol Cell Physiol, January 1, 2007; 292(1): C115 - C124. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Liguzinski and B. Korzeniewski Metabolic control over the oxygen consumption flux in intact skeletal muscle: in silico studies Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1213 - C1224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Birkedal, H. A. Shiels, and M. Vendelin Three-dimensional mitochondrial arrangement in ventricular myocytes: from chaos to order Am J Physiol Cell Physiol, December 1, 2006; 291(6): C1148 - C1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Saks, P. Dzeja, U. Schlattner, M. Vendelin, A. Terzic, and T. Wallimann Cardiac system bioenergetics: metabolic basis of the Frank-Starling law J. Physiol., March 1, 2006; 571(2): 253 - 273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. T. Kinsey, P. Pathi, K. M. Hardy, A. Jordan, and B. R. Locke Does intracellular metabolite diffusion limit post-contractile recovery in burst locomotor muscle? J. Exp. Biol., July 15, 2005; 208(14): 2641 - 2652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vendelin, N. Beraud, K. Guerrero, T. Andrienko, A. V. Kuznetsov, J. Olivares, L. Kay, and V. A. Saks Mitochondrial regular arrangement in muscle cells: a "crystal-like" pattern Am J Physiol Cell Physiol, March 1, 2005; 288(3): C757 - C767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Beard and H. Qian Thermodynamic-based computational profiling of cellular regulatory control in hepatocyte metabolism Am J Physiol Endocrinol Metab, March 1, 2005; 288(3): E633 - E644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bruton, P. Tavi, J. Aydin, H. Westerblad, and J. Lannergren Mitochondrial and myoplasmic [Ca2+] in single fibres from mouse limb muscles during repeated tetanic contractions J. Physiol., August 15, 2003; 551(1): 179 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Andrienko, A. V. Kuznetsov, T. Kaambre, Y. Usson, A. Orosco, F. Appaix, T. Tiivel, P. Sikk, M. Vendelin, R. Margreiter, et al. Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells J. Exp. Biol., June 15, 2003; 206(12): 2059 - 2072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Balaban, S. Bose, S. A. French, and P. R. Territo Role of calcium in metabolic signaling between cardiac sarcoplasmic reticulum and mitochondria in vitro Am J Physiol Cell Physiol, February 1, 2003; 284(2): C285 - C293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Queiroz, Y. Shao, D. A. Berkich, K. F. Lanoue, and F. Ismail-Beigi Thyroid hormone regulation of cardiac bioenergetics: role of intracellular creatine Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2527 - H2533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Vendelin, P. H. M. Bovendeerd, J. Engelbrecht, and T. Arts Optimizing ventricular fibers: uniform strain or stress, but not ATP consumption, leads to high efficiency Am J Physiol Heart Circ Physiol, September 1, 2002; 283(3): H1072 - H1081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kaasik, V. Veksler, E. Boehm, M. Novotova, A. Minajeva, and R. Ventura-Clapier Energetic Crosstalk Between Organelles: Architectural Integration of Energy Production and Utilization Circ. Res., July 20, 2001; 89(2): 153 - 159. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
