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2-agonist
clenbuterol on biochemical and contractile properties of unloaded
soleus fibers of rat
Laboratory of Neuromuscular Plasticity, University of Sciences and Technologies of Lille, F-59655 Villeneuve d'Ascq, France
The effects of clenbuterol
2-agonist administration were
investigated in normal and atrophied [15-day hindlimb-unloaded
(HU)] rat soleus muscles. We showed that clenbuterol had a
specific effect on muscle tissue, since it reduces soleus atrophy
induced by HU. The study of
Ca2+ activation properties
of single skinned fibers revealed that clenbuterol partly prevented the
decrease in maximal tension after HU, with a preferential effect
on fast-twitch fibers. Clenbuterol improved the
Ca2+ sensitivity in slow- and
fast-twitch fibers by shifting the tension-pCa relationship toward
lower Ca2+ concentrations, but
this effect was more marked after HU than in normal conditions. Whole
muscle electrophoresis indicated slow-to-fast transitions of the myosin
heavy chain isoforms for unloaded and for clenbuterol-treated soleus.
The coupling of the two latter conditions did not, however, increase
these phenotypical transformations. Our findings indicated that
clenbuterol had an anabolic action and a
2-adrenergic effect on
muscle fibers and appeared to counteract some effects of unloading
disuse conditions.
2-adrenergic agonist; hindlimb suspension; atrophy; single fibers; myosin heavy chains; calcium and strontium activation characteristics
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